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Gene fumC from Helicobacter pylori 26695: fumarate hydratase
Member of NCBI Protein Clusters PRK00485(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898748
UniProtKB accession
RefSeq Protein accession NP_208117.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: fumC
  • locus tag: HP1325
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction fumarate hydratase
Prof. Vitkup / Confidence:0.901 (References: 19935659, 16507154)
Berkeley Phylogenomics Group Fumarate hydratase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004333 fumarate hydratase activity / (References: 19435885)
Berkeley Phylogenomics Group Aspartate ammonia-lyase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green citG from Bacillus subtilis subsp. subtilis str. 168
(%_identity=66.52; E_val=0.0; BitScore=658.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green fumC from Bradyrhizobium japonicum USDA 110

to see the rest 5 genes click here
GO terms
  • CC: GO:0005737 : cytoplasm : IEA
  • CC: GO:0045239 : tricarboxylic acid cycle enzyme complex : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0004333 : fumarate hydratase activity : IEA
  • BP: GO:0006099 : tricarboxylic acid cycle : IEA
  • BP: GO:0006106 : fumarate metabolic process : IEA
Domain Structure from CDD
  • Fumarase_classII: Class II fumarases. This group contains proteins similar to Escherichia coli fumarase C and the human mitochondrial fum.... (More)
  • fumC: fumarate hydratase; Reviewed

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP1323ribonuclease HII (rnhB)
HP1324hypothetical protein
Metabolic Annotation from Palsson Lab

Metabolic Reaction: FUM

fum[c] + h2o[c] <=> mal-DASH-L[c]
TCA cycle

Source: Ported to COMBREX by Segre's Lab