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Gene murD from Helicobacter pylori 26695: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Member of NCBI Protein Clusters PRK03815(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898752
UniProtKB accession
RefSeq Protein accession NP_207291.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: murD
  • locus tag: HP0494
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Prof. Vitkup 6.3.2.9 / Confidence:0.972 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0008764 UDP-N-acetylmuramoylalanine-D-glutamate ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0047482 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green murD from Escherichia coli str. K-12 substr. MG1655
(%_identity=26.09; E_val=4e-30; BitScore=127.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green cphA from Geminocystis herdmanii PCC 6308

to see the rest 9 genes click here
GO terms
  • BP: GO:0009396 : folic acid and derivative biosynthetic process : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • MF: GO:0008764 : UDP-N-acetylmuramoylalanine-D-glutamate ligase activity : IEA
  • BP: GO:0009252 : peptidoglycan biosynthetic process : IEA
  • MF: GO:0004326 : tetrahydrofolylpolyglutamate synthase activity : IEA
  • BP: GO:0051301 : cell division : IEA
  • BP: GO:0008360 : regulation of cell shape : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0007047 : cellular cell wall organization : IEA
  • BP: GO:0009273 : peptidoglycan-based cell wall biogenesis : IEA
Domain Structure from CDD
  • Mur_ligase_C: Mur ligase family, glutamate ligase domain. This family contains a number of related ligase enzymes which have EC number.... (More)
  • Mur_ligase_M: Mur ligase middle domain.
  • murD: UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
mraYphospho-N-acetylmuramoyl-pentapeptide-transferase
 
 
 
HP0743rod shape-determining protein (mreB)  
 
murCUDP-N-acetylmuramate--L-alanine ligase  
 
murEUDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diamin  
 
HP1565penicillin-binding protein 2 (pbp2)  
 
HP1556cell division protein (ftsI)  
 
HP1560cell division protein (ftsW)  
 
HP0648UDP-N-acetylglucosamine 1-carboxyvinyltransferase  
 
clpPATP-dependent Clp protease proteolytic subunit  
 
murBUDP-N-acetylenolpyruvoylglucosamine reductase  
 
HP0740UDP-MurNac-pentapeptide presynthetase (murF)  
 
HP0387primosome assembly protein PriA  
 
HP1541transcription-repair coupling factor (trcF)  
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: UAMAGS

Name
UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase
Formula
atp[c] + glu-DASH-D[c] + uama[c] -> adp[c] + h[c] + pi[c] + uamag[c]
Pathway
Peptidoglycan Biosynthesis

Source: Ported to COMBREX by Segre's Lab
KEGG