Gene HP0499 from Helicobacter pylori 26695: phospholipase A1 precursor (DR-phospholipase A)
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Member of NCBI Protein Clusters
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CLSK496072(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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898759
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UniProtKB accession
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RefSeq Protein accession
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NP_207296.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP0499
- locus tag: HP0499
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Other Cross References:
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S Structure(s) available in PDB:
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
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Share the same Pfam domain composition with the following experimentally validated proteins
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to see the rest 2 gene click here
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GO terms
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CC:
GO:0016020 : membrane : IEA
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MF:
GO:0004620 : phospholipase activity : IEA
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BP:
GO:0006629 : lipid metabolic process : IEA
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Domain Structure from CDD
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- OMPLA: The outer membrane phospholipase A (OMPLA) is an integral membrane enzyme that catalyses the hydrolysis of acylester bonds in phospholipids using calcium as a cofactor. The enzyme has a fold of transmembrane beta-barrels and is widespread among Gram-negative bacteria, both in pathogens and nonpathogens. In pathogenic bacteria such as Campylobacter coli and Helicobacter pylori OMPLA is involved in pathogenesis and virulence. In nonpathogenic bacteria the physiological function of OMPLA is less clear. The Escherichia coli enzyme is involved in the secretion of bacteriocins, antibacterial peptides that are produced in order to survive under starvation conditions. The enzyme activity of OMPLA is strictly regulated to prevent uncontrolled breakdown of the surrounding phospholipids. The activity of OMPLA can be induced by membrane perturbation and concurs with dimerization of the enzyme..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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 | | HP0497 | sodium- and chloride-dependent transporter | | | HP0498 | sodium- and chloride-dependent transporter | | | HP0500 | DNA polymerase III subunit beta | | | gyrB | DNA gyrase subunit B | |
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