Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene HP0723 from Helicobacter pylori 26695: L-asparaginase II
Member of NCBI Protein Clusters CLSK496177(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898763
UniProtKB accession
RefSeq Protein accession NP_207517.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0723
  • locus tag: HP0723
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction L-asparaginase II
Prof. David Horn 3.5.1: acting on C-N bonds in linear amides / (References: 20034383)
Prof. Vitkup 3.5.1.1 / Confidence:0.838 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group 3.5.1.1: Asparaginase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004622 lysophospholipase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004067 asparaginase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number 3.5.1.1 (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green ansB from Wolinella succinogenes DSM 1740
(%_identity=53.96; E_val=3e-100; BitScore=360.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green ansZ from Bacillus subtilis subsp. subtilis str. 168

to see the rest 4 genes click here
GO terms
  • BP: GO:0006520 : cellular amino acid metabolic process : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0004067 : asparaginase activity : IEA
  • BP: GO:0006528 : asparagine metabolic process : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • Asparaginase: Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspart.... (More)
  • Asparaginase: N/A. L-asparaginase II; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ASNN

Name
L-asparaginase
Formula
asn-DASH-L[c] + h2o[c] -> asp-DASH-L[c] + nh4[c]
Pathway
Asparagine Metabolism

Metabolic Reaction: ASNS2

Name
asparagine synthetase
Formula
asp-DASH-L[c] + atp[c] + nh4[c] -> amp[c] + asn-DASH-L[c] + h[c] + ppi[c]
Pathway
Asparagine Metabolism

Source: Ported to COMBREX by Segre's Lab
KEGG