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Gene HP0723 from Helicobacter pylori 26695: L-asparaginase II
Member of NCBI Protein Clusters CLSK496177(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898763
UniProtKB accession
RefSeq Protein accession NP_207517.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0723
  • locus tag: HP0723
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction L-asparaginase II
Prof. David Horn 3.5.1: acting on C-N bonds in linear amides / (References: 20034383)
Prof. Vitkup / Confidence:0.838 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group Asparaginase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004622 lysophospholipase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004067 asparaginase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green ansB from Wolinella succinogenes DSM 1740
(%_identity=53.96; E_val=3e-100; BitScore=360.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green ansZ from Bacillus subtilis subsp. subtilis str. 168

to see the rest 4 genes click here
GO terms
  • BP: GO:0006520 : cellular amino acid metabolic process : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0004067 : asparaginase activity : IEA
  • BP: GO:0006528 : asparagine metabolic process : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • Asparaginase: Asparaginase (amidohydrolase): Asparaginases are tetrameric enzymes that catalyze the hydrolysis of asparagine to aspart.... (More)
  • Asparaginase: N/A. L-asparaginase II; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ASNN

asn-DASH-L[c] + h2o[c] -> asp-DASH-L[c] + nh4[c]
Asparagine Metabolism

Metabolic Reaction: ASNS2

asparagine synthetase
asp-DASH-L[c] + atp[c] + nh4[c] -> amp[c] + asn-DASH-L[c] + h[c] + ppi[c]
Asparagine Metabolism

Source: Ported to COMBREX by Segre's Lab