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Gene ribH from Helicobacter pylori 26695: 6,7-dimethyl-8-ribityllumazine synthase
Member of NCBI Protein Clusters PRK00061(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898768
UniProtKB accession
RefSeq Protein accession NP_206804.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: ribH
  • locus tag: HP0002
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction 6,7-dimethyl-8-ribityllumazine synthase
Prof. Vitkup / Confidence:0.812 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0000906 6,7-dimethyl-8-ribityllumazine synthase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green ribH from Aquifex aeolicus VF5
(%_identity=50.32; E_val=7e-43; BitScore=167.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green ribH from Bacillus subtilis subsp. subtilis str. 168

to see the rest 6 genes click here
GO terms
  • MF: GO:0004746 : riboflavin synthase activity : IEA
  • CC: GO:0009349 : riboflavin synthase complex : IEA
  • BP: GO:0009231 : riboflavin biosynthetic process : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • DMRL_synthase: 6,7-dimethyl-8-ribityllumazine synthase. riboflavin synthase subunit beta; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
nusBtranscription antitermination protein NusB
HP00032-dehydro-3-deoxyphosphooctonate aldolase
HP0004carbonic anhydrase (icfA)
HP1590hypothetical protein
HP0804bifunctional 3,4-dihydroxy-2-butanone 4-phosphate   
HP1505riboflavin biosynthesis protein (ribG)  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: RBFSa

riboflavin synthase
4r5au[c] + db4p[c] -> dmlz[c] + 2 h2o[c] + pi[c]
Riboflavin Metabolism
Other Genes

Metabolic Reaction: RBFSb

riboflavin synthase
2 dmlz[c] -> 4r5au[c] + ribflv[c]
Riboflavin Metabolism
Other Genes

Source: Ported to COMBREX by Segre's Lab