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Gene coaE from Helicobacter pylori 26695: dephospho-CoA kinase
Member of NCBI Protein Clusters PRK00081(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898770
UniProtKB accession
RefSeq Protein accession NP_207624.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: coaE
  • locus tag: HP0831
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction dephospho-CoA kinase
Prof. Vitkup / Confidence:0.588 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group Dephospho-CoA kinase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004140 dephospho-CoA kinase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms
  • BP: GO:0015937 : coenzyme A biosynthetic process : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016301 : kinase activity : IEA
  • MF: GO:0004140 : dephospho-CoA kinase activity : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • DPCK: Dephospho-coenzyme A kinase (DPCK, EC catalyzes the phosphorylation of dephosphocoenzyme A (dCoA) to yield CoA.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP0829inosine 5'-monophosphate dehydrogenase
gatAaspartyl/glutamyl-tRNA amidotransferase subunit A
HP0833hypothetical protein
speEspermidine synthase
HP1091alpha-ketoglutarate permease (kgtP) 
HP1181multidrug-efflux transporter 
HP0936proline/betaine transporter (proP) 
HP0313nitrite extrusion protein (narK) 
HP1165tetracycline resistance protein tetA(P), putative 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: DPCOAK

dephospho-CoA kinase
atp[c] + dpcoa[c] -> adp[c] + coa[c] + h[c]
Pantothenate and CoA Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)