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Gene HP0003 from Helicobacter pylori 26695: 2-dehydro-3-deoxyphosphooctonate aldolase
Member of NCBI Protein Clusters PRK05198(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898773
UniProtKB accession
RefSeq Protein accession NP_206805.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0003
  • locus tag: HP0003
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 2-dehydro-3-deoxyphosphooctonate aldolase
Prof. Vitkup / Confidence:0.944 (References: 19935659, 16507154)
Berkeley Phylogenomics Group 3-deoxy-8-phosphooctulonate synthase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003849 3-deoxy-7-phosphoheptulonate synthase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green kdsA from Aquifex aeolicus VF5
(%_identity=49.45; E_val=4e-70; BitScore=259.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green kdsA from Aquifex aeolicus VF5

to see the rest 6 genes click here
GO terms
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • BP: GO:0009103 : lipopolysaccharide biosynthetic process : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0008676 : 3-deoxy-8-phosphooctulonate synthase activity : IEA
  • BP: GO:0019294 : keto-3-deoxy-D-manno-octulosonic acid biosynthetic process : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • NeuB: NeuB family. 3-deoxy-7-phosphoheptulonate synthase; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
nusBtranscription antitermination protein NusB
ribH6,7-dimethyl-8-ribityllumazine synthase
HP0004carbonic anhydrase (icfA)
HP1339biopolymer transport protein (exbB) 
HP09573-deoxy-D-manno-octulosonic-acid transferase 
HP0595hypothetical protein 
HP0703response regulator 
lpxBipid-A-disaccharide synthase 
lpxKtetraacyldisaccharide 4'-kinase 
HP02303-deoxy-manno-octulosonate cytidylyltransferase 
HP0280lipid A biosynthesis lauroyl acyltransferase 
HP1340biopolymer transport protein (exbD) 
HP1130biopolymer transport protein (exbB) 
HP1446biopolymer transport protein (exbD) 
HP1375UDP-N-acetylglucosamine acyltransferase 
lpxCUDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine d 
HP1445biopolymer transport protein (exbB) 
HP0605hypothetical protein 
HP1489lipase-like protein 
HP1125peptidoglycan associated lipoprotein precursor (om 
HP1129biopolymer transport protein (exbD) 
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltra 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: KDOPS

3-deoxy -D-manno-octulosonic -acid 8-phosphate synthase
ara5p[c] + h2o[c] + pep[c] -> kdo8p[c] + pi[c]
LPS Biosynthesis - cmpkdo

Source: Ported to COMBREX by Segre's Lab