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Gene HP0004 from Helicobacter pylori 26695: carbonic anhydrase (icfA)
Member of NCBI Protein Clusters CLSK872260(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898779
UniProtKB accession
RefSeq Protein accession NP_206806.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0004
  • locus tag: HP0004
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction carbonic anhydrase
Prof. Vitkup / Confidence:0.16 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004089 carbonate dehydratase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group Carbonate dehydratase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green cynT from Escherichia coli str. K-12 substr. MG1655
(%_identity=33.17; E_val=3e-30; BitScore=126.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green cynT from Escherichia coli str. K-12 substr. MG1655

to see the rest 3 genes click here
GO terms
  • MF: GO:0016829 : lyase activity : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0004089 : carbonate dehydratase activity : IEA
  • BP: GO:0015976 : carbon utilization : IEA
  • MF: GO:0008270 : zinc ion binding : IEA
Domain Structure from CDD
  • beta_CA_cladeB: Carbonic anhydrases (CA) are zinc-containing enzymes that catalyze the reversible hydration of carbon dioxide in a two-s.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
domain fusion
ribH6,7-dimethyl-8-ribityllumazine synthase
HP00032-dehydro-3-deoxyphosphooctonate aldolase
HP0228hypothetical protein 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: HCO3E

HCO3 equilibration reaction
co2[c] + h2o[c] <=> h[c] + hco3[c]
Other Genes

Source: Ported to COMBREX by Segre's Lab