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Gene HP1270 from Helicobacter pylori 26695: NADH dehydrogenase subunit K
Member of NCBI Protein Clusters PRK05715(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898786
UniProtKB accession
RefSeq Protein accession NP_208062.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1270
  • locus tag: HP1270
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction NADH dehydrogenase subunit K
Prof. Vitkup / Confidence:0.577 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008137 NADH dehydrogenase (ubiquinone) activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0015453 oxidoreduction-driven active transmembrane transporter activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
BLASTP hits to experimentally validated proteins
green nqo11 from Paracoccus denitrificans
(%_identity=42.57; E_val=7e-18; BitScore=83.6)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green mrpC from Bacillus pseudofirmus OF4

to see the rest 6 genes click here
GO terms
  • MF: GO:0016651 : oxidoreductase activity, acting on NADH or NADPH : IEA
  • BP: GO:0055114 : oxidation reduction : IEA
  • BP: GO:0006810 : transport : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0048038 : quinone binding : IEA
  • BP: GO:0042773 : ATP synthesis coupled electron transport : IEA
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0019684 : photosynthesis, light reaction : IEA
  • MF: GO:0050136 : NADH dehydrogenase (quinone) activity : IEA
Domain Structure from CDD
  • Oxidored_q2: NADH-ubiquinone/plastoquinone oxidoreductase chain 4L. putative monovalent cation/H+ antiporter subunit C; Reviewed

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
HP1268NADH dehydrogenase subunit I
HP1269NADH dehydrogenase subunit J
HP1271NADH dehydrogenase subunit L
HP1272NADH dehydrogenase subunit M
HP1262NADH dehydrogenase subunit C  
HP1261NADH dehydrogenase subunit B  
HP1263NADH dehydrogenase subunit D  
HP1267NADH dehydrogenase subunit H  
HP1260NADH dehydrogenase subunit A  
HP1273NADH dehydrogenase subunit N  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: NDH_1

NADH dehydrogenase (menaquinone) (complex I)
3 h[c] + mqn6[c] + nadph[c] -> 2 h[e] + mql6[c] + nadp[c]
Respiratory chain
Other Genes

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)