Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene HP1228 from Helicobacter pylori 26695: dinucleoside polyphosphate hydrolase
Member of NCBI Protein Clusters PRK00714(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898789
UniProtKB accession
RefSeq Protein accession NP_208020.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1228
  • locus tag: HP1228
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction dinucleoside polyphosphate hydrolase
Prof. David Horn 3.6.1: acting on Phosphorous containing anhydrides / (References: 20034383)
Prof. Vitkup 3.6.1.13 / Confidence:0.017 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0034431 bis(5'-adenosyl)-hexaphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0034432 bis(5'-adenosyl)-pentaphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042803 protein homodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0030145 manganese ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0000210 NAD+ diphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0000287 magnesium ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0051287 NAD or NADH binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008413 8-oxo-7,8-dihydroguanine triphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0080042 ADP-glucose pyrophosphohydrolase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0047631 ADP-ribose diphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008486 diphosphoinositol-polyphosphate diphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0050072 m7G(5')pppN diphosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0080041 ADP-ribose pyrophosphohydrolase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0010945 CoA pyrophosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004081 bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003729 mRNA binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green RP236 from Rickettsia prowazekii str. Madrid E
(%_identity=44.16; E_val=1e-29; BitScore=123.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green mutT from Escherichia coli str. K-12 substr. MG1655

to see the rest 21 genes click here
GO terms
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0016818 : hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides : IEA
Domain Structure from CDD
  • Ap4A_hydrolase_plant_like: Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Members of this family are w.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
HP1227cytochrome c553
 
HP1229aspartate kinase
 
HP1230hypothetical protein
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: DNMPPA

Name
Dihydroneopterin monophosphate dephosphorylase
Formula
dhpmp[c] + h2o[c] -> dhnpt[c] + pi[c]
Pathway
Folate Biosynthesis

Metabolic Reaction: DNTPPA

Name
Dihydroneopterin triphosphate pyrophosphatase
Formula
ahdt[c] + h2o[c] -> dhpmp[c] + h[c] + ppi[c]
Pathway
Folate Biosynthesis

Source: Ported to COMBREX by Segre's Lab
KEGG