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Gene HP1279 from Helicobacter pylori 26695: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
Member of NCBI Protein Clusters PRK09427(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898793
UniProtKB accession
RefSeq Protein accession NP_208071.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1279
  • locus tag: HP1279
  • aliases: trpC, trpF
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase
Prof. Vitkup / Confidence:0.652 (References: 19935659, 16507154)
Prof. Vitkup / Confidence:0.622 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004640 phosphoribosylanthranilate isomerase activity / (References: 19435885)
Berkeley Phylogenomics Group Phosphoribosylanthranilate isomerase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004425 indole-3-glycerol-phosphate synthase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green trpC from Escherichia coli str. K-12 substr. MG1655
(%_identity=46.17; E_val=3e-106; BitScore=380.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green trpC from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0009073 : aromatic amino acid family biosynthetic process : IEA
  • BP: GO:0006568 : tryptophan metabolic process : IEA
  • MF: GO:0004425 : indole-3-glycerol-phosphate synthase activity : IEA
  • BP: GO:0000162 : tryptophan biosynthetic process : IEA
  • MF: GO:0016831 : carboxy-lyase activity : IEA
  • MF: GO:0004640 : phosphoribosylanthranilate isomerase activity : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
Domain Structure from CDD
  • PRK09427: bifunctional indole-3-glycerol phosphate synthase/phosphoribosylanthranilate isomerase; Provisional
  • PRAI: Phosphoribosylanthranilate isomerase (PRAI) catalyzes the fourth step of the tryptophan biosynthesis, the conversion of .... (More)
  • IGPS: Indole-3-glycerol phosphate synthase (IGPS); an enzyme in the tryptophan biosynthetic pathway, catalyzing the ring closu.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
domain fusion
trpAtryptophan synthase subunit alpha
HP1278tryptophan synthase subunit beta
HP1281anthranilate synthase component II
trpDanthranilate phosphoribosyltransferase
HP0822homoserine dehydrogenase  
HP0098threonine synthase  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: IGPS

indole-3-glycerol-phosphate synthase
2cpr5p[c] + h[c] -> 3ig3p[c] + co2[c] + h2o[c]
Tyr, Phe, Trp Biosynthesis

Metabolic Reaction: PRAIi

phosphoribosylanthranilate isomerase (irreversible)
pran[c] -> 2cpr5p[c]
Tyr, Phe, Trp Biosynthesis

Source: Ported to COMBREX by Segre's Lab