Gene HP0626 from Helicobacter pylori 26695: tetrahydrodipicolinate N-succinyltransferase (dapD)
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Member of NCBI Protein Clusters
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CLSK872399(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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898801
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UniProtKB accession
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RefSeq Protein accession
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NP_207420.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP0626
- locus tag: HP0626
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Source
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Predicted function(s)
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NCBI Protein Cluster Prediction
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2,3,4,5-tetrahydropyridine-2-carboxylate N-succinyltransferase DapD
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Prof. Vitkup
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2.3.1.117 / Confidence:0.106
(References: 19935659, 16507154)
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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BLASTP hits to experimentally validated proteins
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This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
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GO terms
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MF:
GO:0016740 : transferase activity : IEA
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Domain Structure from CDD
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- DapD: Tetrahydrodipicolinate N-succinyltransferase [Amino acid transport and metabolism]
- LbH_THP_succinylT_putative: Putative 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate (THDP) N-succinyltransferase (THP succinyltransferase), C-terminal left-handed parallel alpha-helix (LbH) domain: This group is composed of mostly uncharacterized proteins containing an N-terminal domain of unknown function and a C-terminal LbH domain with similarity to THP succinyltransferase LbH. THP succinyltransferase catalyzes the conversion of tetrahydrodipicolinate and succinyl-CoA to N-succinyltetrahydrodipicolinate and CoA. It is the committed step in the succinylase pathway by which bacteria synthesize L-lysine and meso-diaminopimelate, a component of peptidoglycan. The enzyme is trimeric and displays the left-handed parallel alpha-helix (LbH) structural motif encoded by the hexapeptide repeat motif..... (More)
See domain structure on NCBI Conserved Domain Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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 | | ispG | 4-hydroxy-3-methylbut-2-en-1-yl diphosphate syntha | | | HP0628 | hypothetical protein | |
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Metabolic Annotation from Palsson Lab
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Metabolic Reaction: THDPS
- Name
- tetrahydrodipicolinate succinylase
- Formula
- h2o[c] + succoa[c] + thdp[c] -> coa[c] + sl2a6o[c]
- Pathway
- Lysine/ Threonine Biosynthesis
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KEGG
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