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Gene HP0701 from Helicobacter pylori 26695: DNA gyrase subunit A
Member of NCBI Protein Clusters PRK05560(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898803
UniProtKB accession
RefSeq Protein accession NP_207495.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0701
  • locus tag: HP0701
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA gyrase subunit A
Prof. David Horn 5.99.1.3: DNA topoisomerase (ATP-hydrolysing) / (References: 20034383)
Berkeley Phylogenomics Group 5.99.1.3: DNA topoisomerase (ATP-hydrolyzing). / (References: 19435885)
Berkeley Phylogenomics Group GO:0008094 DNA-dependent ATPase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042803 protein homodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005080 protein kinase C binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008022 protein C-terminus binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003682 chromatin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0000400 four-way junction DNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005229 intracellular calcium activated chloride channel activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0043130 ubiquitin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008144 drug binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043566 structure-specific DNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042826 histone deacetylase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0000182 rDNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043565 sequence-specific DNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005245 voltage-gated calcium channel activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003729 mRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0046982 protein heterodimerization activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number 5.99.1.3 (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green gyrA from Staphylococcus aureus
(%_identity=49.39; E_val=0.0; BitScore=783.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green gyrA from Staphylococcus aureus

to see the rest 7 genes click here
GO terms
  • CC: GO:0005694 : chromosome : IEA
  • MF: GO:0003916 : DNA topoisomerase activity : IEA
  • MF: GO:0003918 : DNA topoisomerase (ATP-hydrolyzing) activity : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0006265 : DNA topological change : IEA
  • BP: GO:0006259 : DNA metabolic process : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD
  • TOP4c: DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A su.... (More)
  • DNA_gyraseA_C: DNA gyrase C-terminal domain, beta-propeller. This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC .... (More)
  • PRK05560: DNA gyrase subunit A; Validated

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
domain fusion
HP0699hypothetical protein
 
  
HP0700diacylglycerol kinase (dgkA)
 
  
HP0703response regulator
 
  
HP0702hypothetical protein
 
  
gyrBDNA gyrase subunit B