COMBREX: HP0701 in Helicobacter pylori 26695

Gene HP0701 from Helicobacter pylori 26695: DNA gyrase subunit A

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Summary

Member of NCBI Protein Clusters	PRK05560(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID	898803
UniProtKB accession	P48370
RefSeq Protein accession	NP_207495.1 (PROVISIONAL)
Gene Symbol(s)	symbol: HP0701 locus tag: HP0701
Organism	Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:	S Structure(s) available in PDB: C Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.) U Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium). Protein described in EcoCyc:

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Actions You Can Take

	Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
	Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
	Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
	Post a comment about this gene to appear on this page (info).

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Function Predictions

Source	Predicted function(s)
NCBI Protein Cluster Prediction	DNA gyrase subunit A
Prof. David Horn	5.99.1.3: DNA topoisomerase (ATP-hydrolysing) / (References: 20034383)
Berkeley Phylogenomics Group	5.99.1.3: DNA topoisomerase (ATP-hydrolyzing). / (References: 19435885)
Berkeley Phylogenomics Group	GO:0008094 DNA-dependent ATPase activity / (References: 19435885)
Berkeley Phylogenomics Group	GO:0042803 protein homodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group	GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0005080 protein kinase C binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0008022 protein C-terminus binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0003682 chromatin binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0000400 four-way junction DNA binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0005229 intracellular calcium activated chloride channel activity / (References: 19435885)
Berkeley Phylogenomics Group	GO:0043130 ubiquitin binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0008144 drug binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0043566 structure-specific DNA binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0042826 histone deacetylase binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0000182 rDNA binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0043565 sequence-specific DNA binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0003918 DNA topoisomerase (ATP-hydrolyzing) activity / (References: 19435885)
Berkeley Phylogenomics Group	GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0005245 voltage-gated calcium channel activity / (References: 19435885)
Berkeley Phylogenomics Group	GO:0003729 mRNA binding / (References: 19435885)
Berkeley Phylogenomics Group	GO:0046982 protein heterodimerization activity / (References: 19435885)

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Supporting Functional Information

Functional Status

blue (function predicted, no experimental evidence)

Source of prediction

NCBI Protein Clusters info

EC number

5.99.1.3 (See reaction via BRENDA)) (Source: BRENDA)

BLASTP hits to experimentally validated proteins

gyrA from Staphylococcus aureus
(%_identity=49.39; E_val=0.0; BitScore=783.0)

other hits with E-value < 1e-05

Share the same Pfam domain composition with the following experimentally validated proteins

gyrA from Staphylococcus aureus

to see the rest 7 genes click here

GO terms

CC: GO:0005694 : chromosome : IEA
MF: GO:0003916 : DNA topoisomerase activity : IEA
MF: GO:0003918 : DNA topoisomerase (ATP-hydrolyzing) activity : IEA
MF: GO:0005524 : ATP binding : IEA
BP: GO:0006265 : DNA topological change : IEA
BP: GO:0006259 : DNA metabolic process : IEA
MF: GO:0016853 : isomerase activity : IEA
MF: GO:0003677 : DNA binding : IEA
MF: GO:0000166 : nucleotide binding : IEA

Domain Structure from CDD

TOP4c: DNA Topoisomerase, subtype IIA; domain A'; bacterial DNA topoisomerase IV (C subunit, ParC), bacterial DNA gyrases (A su.... (More)
DNA_gyraseA_C: DNA gyrase C-terminal domain, beta-propeller. This repeat is found as 6 tandem copies at the C-termini of GyrA and ParC .... (More)
PRK05560: DNA gyrase subunit A; Validated

See domain structure on NCBI Conserved Domain Database

Domain structure from Pfam

See domain structure on Pfam Database

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Functionally Linked Genes

The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com


HP0699	hypothetical protein
HP0700	diacylglycerol kinase (dgkA)
HP0703	response regulator
HP0702	hypothetical protein
gyrB	DNA gyrase subunit B

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