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Gene eno from Helicobacter pylori 26695: phosphopyruvate hydratase
Member of NCBI Protein Clusters PRK00077(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898806
UniProtKB accession
RefSeq Protein accession NP_206953.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: eno
  • locus tag: HP0154
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction phosphopyruvate hydratase
Prof. Vitkup / Confidence:0.813 (References: 19935659, 16507154)
Berkeley Phylogenomics Group Phosphopyruvate hydratase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green eno from Bacillus subtilis subsp. subtilis str. 168
(%_identity=56.9; E_val=2e-138; BitScore=487.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
blue eno from Salmonella enterica subsp. enterica serovar Dublin str. CT_02021853

to see the rest 56 genes click here
GO terms
  • MF: GO:0046872 : metal ion binding : IEA
  • BP: GO:0006096 : glycolysis : IEA
  • MF: GO:0004634 : phosphopyruvate hydratase activity : IEA
  • CC: GO:0009986 : cell surface : IEA
  • CC: GO:0000015 : phosphopyruvate hydratase complex : IEA
  • CC: GO:0005576 : extracellular region : IEA
  • MF: GO:0000287 : magnesium ion binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0016829 : lyase activity : IEA
Domain Structure from CDD
  • eno: phosphopyruvate hydratase; Provisional
  • enolase: Enolase: Enolases are homodimeric enzymes that catalyse the reversible dehydration of 2-phospho-D-glycerate to phosphoen.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
recArecombinase A
HP0155hypothetical protein
HP0156hypothetical protein
pgkphosphoglycerate kinase 
tpiAtriosephosphate isomerase 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ENO

2pg[c] <=> h2o[c] + pep[c]

Source: Ported to COMBREX by Segre's Lab