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Gene HP1247 from Helicobacter pylori 26695: DNA polymerase III subunit delta
Member of NCBI Protein Clusters PRK08487(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898813
UniProtKB accession
RefSeq Protein accession NP_208039.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1247
  • locus tag: HP1247
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction DNA polymerase III subunit delta
COMBREX jhp1168 protein jhp_1168 (source organism: Helicobacter pylori J99; strain specific ID: NCBI_TaxID=85963) [More information on this prediction]
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Source References Functional description
GSDB Under Review protein HP_1247 (source organism: Helicobacter pylori; strain specific ID: NCBI_TaxID=210)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • BP: GO:0006260 : DNA replication : IEA
  • MF: GO:0003887 : DNA-directed DNA polymerase activity : IEA
  • CC: GO:0009360 : DNA polymerase III complex : IEA
  • MF: GO:0016779 : nucleotidyltransferase activity : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • MF: GO:0005515 : protein binding : IPI
Domain Structure from CDD
  • DNA_pol3_delta: DNA polymerase III, delta subunit. DNA polymerase III, delta subunit (EC is required for, along with delta' sub.... (More)
  • PRK08487: DNA polymerase III subunit delta; Validated

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
dnaX , HPAG1_1190 , HPG27_1192 , HPP12_1213 , HPSH_06460 , jhp1168
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP1248virulence associated protein homolog (vacB)
HP1245single-stranded DNA-binding protein
rpsF30S ribosomal protein S6
aroEshikimate 5-dehydrogenase
dnaEDNA polymerase III subunit alpha 
rpmI50S ribosomal protein L35 
greAtranscription elongation factor GreA 
HP0088RNA polymerase sigma factor RpoD 
rbfAribosome-binding factor A 
nusBtranscription antitermination protein NusB 
rplI50S ribosomal protein L9 
secApreprotein translocase subunit SecA 
rpsT30S ribosomal protein S20 
HP0717DNA polymerase III subunits gamma and tau 
HP0955prolipoprotein diacylglyceryl transferase 
rplU50S ribosomal protein L21 
tsfelongation factor Ts 
infCtranslation initiation factor IF-3 
rpmE50S ribosomal protein L31 
smpBSsrA-binding protein 
dnaAchromosomal replication initiation protein 
lspAlipoprotein signal peptidase 
tigtrigger factor 
trmDtRNA (guanine-N(1)-)-methyltransferase 
secEpreprotein translocase membrane subunit 
defpeptide deformylase 
HP1051hypothetical protein 
ligANAD-dependent DNA ligase LigA 
rplT50S ribosomal protein L20 
mraWS-adenosyl-methyltransferase MraW 
HP1362replicative DNA helicase 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)