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Gene HP1281 from Helicobacter pylori 26695: anthranilate synthase component II
Member of NCBI Protein Clusters PRK05670(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898814
UniProtKB accession
RefSeq Protein accession NP_208073.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1281
  • locus tag: HP1281
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction anthranilate synthase component II
Prof. Vitkup / Confidence:0.838 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004151 dihydroorotase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004425 indole-3-glycerol-phosphate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003922 GMP synthase (glutamine-hydrolyzing) activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004088 carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity / (References: 19435885)
Berkeley Phylogenomics Group Dihydroorotase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0019899 enzyme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004049 anthranilate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0002134 UTP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003921 GMP synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0070335 aspartate binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004070 aspartate carbamoyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004048 anthranilate phosphoribosyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0046820 4-amino-4-deoxychorismate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004672 protein kinase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green trpG from Serratia marcescens
(%_identity=39.04; E_val=5e-42; BitScore=165.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green hisH from Thermus thermophilus HB8

to see the rest 9 genes click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • BP: GO:0009073 : aromatic amino acid family biosynthetic process : IEA
  • BP: GO:0006541 : glutamine metabolic process : IEA
  • BP: GO:0000162 : tryptophan biosynthetic process : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • MF: GO:0004049 : anthranilate synthase activity : IEA
Domain Structure from CDD
  • GATase: Glutamine amidotransferase class-I.
  • GATase1_Anthranilate_Synthase: Type 1 glutamine amidotransferase (GATase1) domain found in Anthranilate synthase. Type 1 glutamine amidotransferase (GA.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
domain fusion
HP1283hypothetical protein
HP1279bifunctional indole-3-glycerol phosphate synthase/
HP1282anthranilate synthase component I
trpDanthranilate phosphoribosyltransferase
HP0293para-aminobenzoate synthetase (pabB)  
guaAGMP synthase   
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ANS

anthranilate synthase
chor[c] + gln-DASH-L[c] -> anth[c] + glu-DASH-L[c] + h[c] + pyr[c]
Tryptophan Biosynthesis
Other Genes

Metabolic Reaction: ANS2

anthranilate synthase 2
chor[c] + nh4[c] -> anth[c] + h2o[c] + h[c] + pyr[c]
Chorismate Metabolism
Other Genes

Source: Ported to COMBREX by Segre's Lab