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Gene aroE from Helicobacter pylori 26695: shikimate 5-dehydrogenase
Member of NCBI Protein Clusters PRK00258(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898819
UniProtKB accession
RefSeq Protein accession NP_208041.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: aroE
  • locus tag: HP1249
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 3PHG 3PHH 3PHI 3PHJ
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction shikimate 5-dehydrogenase
Prof. Vitkup / Confidence:0.611 (References: 19935659, 16507154)
Berkeley Phylogenomics Group 3-dehydroquinate dehydratase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004764 shikimate 5-dehydrogenase activity / (References: 19435885)
Berkeley Phylogenomics Group Shikimate dehydrogenase. / (References: 19435885)
Berkeley Phylogenomics Group Glutamyl-tRNA reductase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004765 shikimate kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003856 3-dehydroquinate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003870 5-aminolevulinate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003855 3-dehydroquinate dehydratase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green aroE from Escherichia coli str. K-12 substr. MG1655
(%_identity=34.75; E_val=2e-27; BitScore=117.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green aroD from Bacillus subtilis subsp. subtilis str. 168

to see the rest 7 genes click here
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0050661 : NADP or NADPH binding : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0005488 : binding : IEA
  • BP: GO:0009073 : aromatic amino acid family biosynthetic process : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0004764 : shikimate 5-dehydrogenase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • NAD_bind_Shikimate_DH: NAD(P) binding domain of Shikimate dehydrogenase. Shikimate dehydrogenase (DH) is an amino acid DH family member. Shikim.... (More)
  • Shikimate_dh_N: Shikimate dehydrogenase substrate binding domain. This domain is the substrate binding domain of shikimate dehydrogenase.
  • aroE: shikimate 5-dehydrogenase. This model finds proteins from prokaryotes and functionally equivalent domains from larger, m.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
domain fusion
HP1251oligopeptide ABC transporter, permease protein (op
HP1247DNA polymerase III subunit delta
HP1248virulence associated protein homolog (vacB)
HP1250hypothetical protein
HP0663chorismate synthase 
HP04013-phosphoshikimate 1-carboxyvinyltransferase 
aroB3-dehydroquinate synthase  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: SHK3Dr

shikimate dehydrogenase
3dhsk[c] + h[c] + nadph[c] <=> nadp[c] + skm[c]
Chorismate Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)