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Gene HP1222 from Helicobacter pylori 26695: D-lactate dehydrogenase (dld)
Member of NCBI Protein Clusters CLSK872525(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898825
UniProtKB accession
RefSeq Protein accession NP_208014.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1222
  • locus tag: HP1222
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction D-lactate dehydrogenase
Prof. Vitkup / Confidence:0.014 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004458 D-lactate dehydrogenase (cytochrome) activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0051990 (R)-2-hydroxyglutarate dehydrogenase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0050660 FAD binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003779 actin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019154 glycolate dehydrogenase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0009055 : electron carrier activity : IEA
  • MF: GO:0050660 : FAD binding : IEA
  • MF: GO:0051536 : iron-sulfur cluster binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
Domain Structure from CDD
  • GlpC: Fe-S oxidoreductase [Energy production and conversion]
  • FAD_binding_4: FAD binding domain. This family consists of various enzymes that use FAD as a co-factor, most of the enzymes are similar.... (More)
  • GlcD: FAD/FMN-containing dehydrogenases [Energy production and conversion]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
domain fusion
HP1220ABC transporter, ATP-binding protein (yhcG)
HP1221hypothetical protein
HP0509glycolate oxidase subunit (glcD) 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: LDH_D1

D-lactate dehydrogenase
lac-DASH-D[c] + mqn6[c] <=> mql6[c] + pyr[c]
Respiratory chain

Source: Ported to COMBREX by Segre's Lab