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Gene HP0822 from Helicobacter pylori 26695: homoserine dehydrogenase
Member of NCBI Protein Clusters PRK06349(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898826
UniProtKB accession
RefSeq Protein accession NP_207615.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0822
  • locus tag: HP0822
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction homoserine dehydrogenase
Prof. Vitkup / Confidence:0.852 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030234 enzyme regulator activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group Homoserine dehydrogenase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003984 acetolactate synthase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0050661 : NADP or NADPH binding : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0006520 : cellular amino acid metabolic process : IEA
  • BP: GO:0009086 : methionine biosynthetic process : IEA
  • BP: GO:0009082 : branched chain family amino acid biosynthetic process : IEA
  • BP: GO:0009088 : threonine biosynthetic process : IEA
  • BP: GO:0009097 : isoleucine biosynthetic process : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
  • MF: GO:0016597 : amino acid binding : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0004412 : homoserine dehydrogenase activity : IEA
  • MF: GO:0005488 : binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
Domain Structure from CDD
  • Homoserine_dh: Homoserine dehydrogenase.
  • ACT_HSDH-Hom: ACT_HSDH_Hom CD includes the C-terminal ACT domain of the NAD(P)H-dependent, homoserine dehydrogenase (HSDH) and related.... (More)
  • PRK06349: homoserine dehydrogenase; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
domain fusion
HP0820hypothetical protein
uvrCexcinuclease ABC subunit C
HP0823hypothetical protein
HP0824thioredoxin (trxA)
trpDanthranilate phosphoribosyltransferase 
HP1279bifunctional indole-3-glycerol phosphate synthase/ 
HP0098threonine synthase 
HP1229aspartate kinase  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: HSDy

homoserine dehydrogenase (NADPH)
hom-DASH-L[c] + nadp[c] <=> aspsa[c] + h[c] + nadph[c]
Lysine/ Threonine Biosynthesis

Source: Ported to COMBREX by Segre's Lab