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Gene panC from Helicobacter pylori 26695: pantoate--beta-alanine ligase
Member of NCBI Protein Clusters PRK00380(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898828
UniProtKB accession
RefSeq Protein accession NP_206808.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: panC
  • locus tag: HP0006
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction pantoate--beta-alanine ligase
Prof. Vitkup 6.3.2.1 / Confidence:0.887 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004592 pantoate-beta-alanine ligase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
blue panC from Mycobacterium tuberculosis CDC1551

to see the rest 3 genes click here
GO terms
  • BP: GO:0015940 : pantothenate biosynthetic process : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • MF: GO:0004592 : pantoate-beta-alanine ligase activity : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • MF: GO:0005524 : ATP binding : IEA
Domain Structure from CDD
  • PanC: Pantoate-beta-alanine ligase. PanC Pantoate-beta-alanine ligase, also known as pantothenate synthase, catalyzes the for.... (More)
  • panC: pantoate--beta-alanine ligase. This family is pantoate--beta-alanine ligase, the last enzyme of pantothenate biosynthesis.

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
HP0005OMP decarboxylase; OMPDCase; OMPdecase
 
 
panB3-methyl-2-oxobutanoate hydroxymethyltransferase 
 
HP0034aspartate alpha-decarboxylase 
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: PANTS

Name
pantothenate synthase
Formula
ala-DASH-B[c] + atp[c] + pant-DASH-R[c] -> amp[c] + h[c] + pnto-DASH-R[c] + ppi[c]
Pathway
Pantothenate and CoA Biosynthesis

Source: Ported to COMBREX by Segre's Lab
KEGG
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)