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Gene HP0116 from Helicobacter pylori 26695: DNA topoisomerase I
Member of NCBI Protein Clusters PRK05582(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898836
UniProtKB accession
RefSeq Protein accession NP_206916.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0116
  • locus tag: HP0116
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction DNA topoisomerase I
Berkeley Phylogenomics Group GO:0004520 endodeoxyribonuclease activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003917 DNA topoisomerase type I activity / (References: 19435885)
Berkeley Phylogenomics Group DNA topoisomerase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green topA from Bacillus subtilis subsp. subtilis str. 168
(%_identity=41.12; E_val=2e-153; BitScore=537.0)

other hits with E-value < 1e-05
GO terms
  • CC: GO:0005694 : chromosome : IEA
  • MF: GO:0003917 : DNA topoisomerase type I activity : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0003916 : DNA topoisomerase activity : IEA
  • BP: GO:0006265 : DNA topological change : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016853 : isomerase activity : IEA
  • BP: GO:0006259 : DNA metabolic process : IEA
  • MF: GO:0003676 : nucleic acid binding : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • BP: GO:0006268 : DNA unwinding during replication : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD
  • TOP1Ac: DNA Topoisomerase, subtype IA; DNA-binding, ATP-binding and catalytic domain of bacterial DNA topoisomerases I and III, .... (More)
  • PRK05582: DNA topoisomerase I; Validated
  • zf-C4_Topoisom: Topoisomerase DNA binding C4 zinc finger. Archaeal DNA polymerase II, large subunit [DNA replication, recombination, and repair]
  • TOPRIM_TopoIA_TopoI: TOPRIM_TopoIA_TopoI: The topoisomerase-primase (TORPIM) domain found in members of the type IA family of DNA topoisomera.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
domain fusion
HP0117hypothetical protein
HP0440DNA topoisomerase I (topA)