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Gene HP1218 from Helicobacter pylori 26695: glycinamide ribonucleotide synthetase (purD)
Member of NCBI Protein Clusters CLSK496415(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898842
UniProtKB accession
RefSeq Protein accession NP_208010.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1218
  • locus tag: HP1218
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction phosphoribosylamine--glycine ligase
Prof. Vitkup / Confidence:0.437 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004637 phosphoribosylamine-glycine ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004641 phosphoribosylformylglycinamidine cyclo-ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004644 phosphoribosylglycinamide formyltransferase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green purD from Escherichia coli str. K-12 substr. MG1655
(%_identity=28.77; E_val=1e-53; BitScore=205.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green purD from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • BP: GO:0006164 : purine nucleotide biosynthetic process : IEA
  • BP: GO:0009113 : purine base biosynthetic process : IEA
  • MF: GO:0004637 : phosphoribosylamine-glycine ligase activity : IEA
Domain Structure from CDD
  • GARS_N: Phosphoribosylglycinamide synthetase, N domain. Phosphoribosylglycinamide synthetase catalyses the second step in the de.... (More)
  • GARS_C: Phosphoribosylglycinamide synthetase, C domain. Phosphoribosylglycinamide synthetase catalyses the second step in the de.... (More)
  • CPSase_L_D2: Carbamoyl-phosphate synthase L chain, ATP binding domain. Members of this protein family contain a region of homology to.... (More)
  • purD: phosphoribosylamine--glycine ligase. This enzyme appears as a monofunctional protein in prokaryotes but as part of a lar.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
domain fusion
HP1216hypothetical protein
HP1217hypothetical protein
HP1434formyltetrahydrofolate hydrolase (purU) 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: PRAGSr

phosphoribosylglycinamide synthase
atp[c] + gly[c] + pram[c] <=> adp[c] + gar[c] + h[c] + pi[c]
IMP Synthesis

Source: Ported to COMBREX by Segre's Lab