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Gene HP1268 from Helicobacter pylori 26695: NADH dehydrogenase subunit I
Member of NCBI Protein Clusters PRK05888(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898843
UniProtKB accession
RefSeq Protein accession NP_208060.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1268
  • locus tag: HP1268
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction NADH dehydrogenase subunit I
Prof. Vitkup / Confidence:0.657 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green from Methanosarcina barkeri

to see the rest 42 genes click here
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0016651 : oxidoreductase activity, acting on NADH or NADPH : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0051536 : iron-sulfur cluster binding : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • MF: GO:0051539 : 4 iron, 4 sulfur cluster binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0048038 : quinone binding : IEA
  • MF: GO:0009055 : electron carrier activity : IEA
  • CC: GO:0016020 : membrane : IEA
  • MF: GO:0005506 : iron ion binding : IEA
  • BP: GO:0019684 : photosynthesis, light reaction : IEA
  • MF: GO:0050136 : NADH dehydrogenase (quinone) activity : IEA
Domain Structure from CDD
  • NuoI: NADH-quinone oxidoreductase, chain I. This model represents the I subunit (one of 14: A->N) of the NADH-quinone oxidored.... (More)
  • Fer4: 4Fe-4S binding domain. Superfamily includes proteins containing domains which bind to iron-sulfur clusters. Members incl.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
HP1270NADH dehydrogenase subunit K
HP1266NADH dehydrogenase subunit G
HP1267NADH dehydrogenase subunit H
HP1269NADH dehydrogenase subunit J
HP1263NADH dehydrogenase subunit D  
HP1273NADH dehydrogenase subunit N  
HP1261NADH dehydrogenase subunit B  
HP1262NADH dehydrogenase subunit C  
HP1260NADH dehydrogenase subunit A  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: NDH_1

NADH dehydrogenase (menaquinone) (complex I)
3 h[c] + mqn6[c] + nadph[c] -> 2 h[e] + mql6[c] + nadp[c]
Respiratory chain
Other Genes

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)