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Gene HP0804 from Helicobacter pylori 26695: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Member of NCBI Protein Clusters PRK09314(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898852
UniProtKB accession
RefSeq Protein accession NP_207597.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0804
  • locus tag: HP0804
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein
Prof. Vitkup / Confidence:0.513 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008686 3,4-dihydroxy-2-butanone-4-phosphate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group 3,4-dihydroxy-2-butanone-4-phosphate synthase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003935 GTP cyclohydrolase II activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms
  • MF: GO:0000287 : magnesium ion binding : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0003935 : GTP cyclohydrolase II activity : IEA
  • BP: GO:0009231 : riboflavin biosynthetic process : IEA
  • MF: GO:0008686 : 3,4-dihydroxy-2-butanone-4-phosphate synthase activity : IEA
  • MF: GO:0030145 : manganese ion binding : IEA
Domain Structure from CDD
  • PRK09314: bifunctional 3,4-dihydroxy-2-butanone 4-phosphate synthase/GTP cyclohydrolase II protein; Provisional
  • DHBP_synthase: 3,4-dihydroxy-2-butanone 4-phosphate synthase. 3,4-dihydroxy-2-butanone 4-phosphate synthase; Validated
  • GTP_cyclohydro2: N/A. GTP cyclohydrolase II; Reviewed

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
domain fusion
ribAGTP cyclohydrolase II
HP0803hypothetical protein
HP0805lipooligosaccharide 5G8 epitope biosynthesis-assoc
ribH6,7-dimethyl-8-ribityllumazine synthase  
HP1574riboflavin synthase subunit alpha  
HP1505riboflavin biosynthesis protein (ribG)  
Metabolic Annotation from Palsson Lab

Metabolic Reaction: DB4PS

3,4-Dihydroxy-2-butanone-4-phosphate synthase
ru5p-DASH-D[c] -> db4p[c] + for[c] + h[c]
Riboflavin Metabolism

Source: Ported to COMBREX by Segre's Lab