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Gene HP0354 from Helicobacter pylori 26695: 1-deoxy-D-xylulose-5-phosphate synthase
Member of NCBI Protein Clusters PRK05444(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898853
UniProtKB accession
RefSeq Protein accession NP_207152.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0354
  • locus tag: HP0354
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction 1-deoxy-D-xylulose-5-phosphate synthase
Prof. Vitkup / Confidence:0.892 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0008661 1-deoxy-D-xylulose-5-phosphate synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0048029 monosaccharide binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0000287 magnesium ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004802 transketolase activity / (References: 19435885)
Berkeley Phylogenomics Group Transketolase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0032403 protein complex binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030976 thiamin pyrophosphate binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green dxs from Escherichia coli str. K-12 substr. MG1655
(%_identity=41.11; E_val=4e-125; BitScore=443.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green dxs from Pseudomonas aeruginosa PAO1

to see the rest 2 gene click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0009228 : thiamin biosynthetic process : IEA
  • MF: GO:0008661 : 1-deoxy-D-xylulose-5-phosphate synthase activity : IEA
  • BP: GO:0016114 : terpenoid biosynthetic process : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • BP: GO:0008299 : isoprenoid biosynthetic process : IEA
  • MF: GO:0016624 : oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • Transketolase_C: Transketolase, C-terminal domain. The C-terminal domain of transketolase has been proposed as a regulatory molecule binding site.
  • dxs: 1-deoxy-D-xylulose-5-phosphate synthase. DXP synthase is a thiamine diphosphate-dependent enzyme related to transketolas.... (More)
  • TPP_DXS: Thiamine pyrophosphate (TPP) family, DXS subfamily, TPP-binding module; 1-Deoxy-D-xylulose-5-phosphate synthase (DXS) is.... (More)
  • TPP_PYR_DXS_TK_like: Pyrimidine (PYR) binding domain of 1-deoxy-D-xylulose-5-phosphate synthase (DXS), transketolase (TK), and related protei.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
fliGflagellar motor switch protein G
fliHflagellar assembly protein H
HP0356hypothetical protein
HP0355GTP-binding protein LepA
HP14434-diphosphocytidyl-2-C-methyl-D-erythritol kinase 
ispH4-hydroxy-3-methylbut-2-enyl diphosphate reductase 
HP0772N-acetylmuramoyl-L-alanine amidase (amiA) 
HP0087hypothetical protein 
ispG4-hydroxy-3-methylbut-2-en-1-yl diphosphate syntha 
ispDFbifunctional 2-C-methyl-D-erythritol 4-phosphate c 
HP02161-deoxy-D-xylulose 5-phosphate reductoisomerase 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: DXPS

1-deoxy-D-xylulose 5-phosphate synthase
g3p[c] + h[c] + pyr[c] -> co2[c] + dxyl5p[c]
Isoprenoid Biosynthesis

Source: Ported to COMBREX by Segre's Lab