Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene hemH from Helicobacter pylori 26695: ferrochelatase
Member of NCBI Protein Clusters PRK00035(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898870
UniProtKB accession
RefSeq Protein accession NP_207174.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: hemH
  • locus tag: HP0376
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction ferrochelatase
Prof. Vitkup / Confidence:0.644 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0020037 heme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030350 iron-responsive element binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004325 ferrochelatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group Ferrochelatase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green hemH from Caulobacter crescentus CB15
(%_identity=30.65; E_val=1e-31; BitScore=132.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green hemH from Staphylococcus aureus subsp. aureus N315

to see the rest 4 genes click here
GO terms
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0004325 : ferrochelatase activity : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • BP: GO:0006783 : heme biosynthetic process : IEA
  • BP: GO:0006779 : porphyrin biosynthetic process : IEA
Domain Structure from CDD
  • Ferrochelatase_C: Ferrochelatase, C-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme bios.... (More)
  • hemH: ferrochelatase. Human ferrochelatase, found at the mitochondrial inner membrane inner surface, was shown in an active re.... (More)
  • Ferrochelatase_N: Ferrochelatase, N-terminal domain: Ferrochelatase (protoheme ferrolyase or HemH) is the terminal enzyme of the heme bios.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP0378cytochrome c biogenesis protein (ycf5)
HP0377thiol:disulfide interchange protein (dsbC), putati
hemEuroporphyrinogen decarboxylase 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: FCLT

fe2[c] + ppp9[c] -> 2 h[c] + pheme[c]
Heme biosynthesis

Source: Ported to COMBREX by Segre's Lab