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Gene HP0380 from Helicobacter pylori 26695: glutamate dehydrogenase
Member of NCBI Protein Clusters PRK09414(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898871
UniProtKB accession
RefSeq Protein accession NP_207178.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0380
  • locus tag: HP0380
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction glutamate dehydrogenase
Prof. Vitkup 1.4.1.4 / Confidence:0.489 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group 1.4.1.4: Glutamate dehydrogenase (NADP(+)). / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0070728 leucine binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005507 copper ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043531 ADP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004352 glutamate dehydrogenase activity / (References: 19435885)
Berkeley Phylogenomics Group 1.4.1.3: Glutamate dehydrogenase (NAD(P)(+)). / (References: 19435885)
Berkeley Phylogenomics Group GO:0070403 NAD binding / (References: 19435885)
Berkeley Phylogenomics Group 1.4.1.2: Glutamate dehydrogenase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0050897 cobalt ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005525 GTP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004354 glutamate dehydrogenase (NADP+) activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green gdhA from Prevotella ruminicola
(%_identity=58.09; E_val=3e-145; BitScore=510.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green gudB from Bacillus subtilis subsp. subtilis str. 168

to see the rest 15 genes click here
GO terms
  • MF: GO:0016639 : oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor : IEA
  • BP: GO:0055114 : oxidation reduction : IEA
  • BP: GO:0006520 : cellular amino acid metabolic process : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0004354 : glutamate dehydrogenase (NADP+) activity : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0005488 : binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
Domain Structure from CDD
  • NAD_bind_2_Glu_DH: NAD(P) binding domain of glutamate dehydrogenase, subgroup 2. Amino acid dehydrogenase (DH) is a widely distributed fami.... (More)
  • PRK09414: glutamate dehydrogenase; Provisional
  • ELFV_dehydrog_N: Glu/Leu/Phe/Val dehydrogenase, dimerization domain.

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
HP0382zinc-metallo protease (YJR117W)
 
HP0381protoporphyrinogen oxidase (hemK)
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: GLUDy

Name
glutamate dehydrogenase (NADP)
Formula
glu-DASH-L[c] + h2o[c] + nadp[c] <=> akg[c] + h[c] + nadph[c] + nh4[c]
Pathway
Glutamate Metabolism

Source: Ported to COMBREX by Segre's Lab
KEGG