Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
Genes with solved structures in PDB
Genes with Pfam domains shared with human proteins
Genes with products purified by PSI
Genes cloned by PSI
close options


Gene HP0388 from Helicobacter pylori 26695: hypothetical protein
Member of NCBI Protein Clusters CLSK551844(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898872
UniProtKB accession
RefSeq Protein accession NP_207186.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0388
  • locus tag: HP0388
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction methyltransferase
Prof. David Horn 2.1.1: methyltransferase / (References: 20034383)
Prof. David Horn tRNA (guanine-N1-)-methyltransferase / (References: 20034383)
Prof. Vitkup / Confidence:0.002 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0000234 phosphoethanolamine N-methyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003838 sterol 24-C-methyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group Sterol 24-C-methyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group Phosphoethanolamine N-methyltransferase. / (References: 19435885)
Combrex_01 ortholog of E. coli cmoA / Anton BP unpublished
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green yjhP from Escherichia coli str. K-12 substr. MG1655

to see the rest 7 genes click here
GO terms
  • BP: GO:0008033 : tRNA processing : IEA
  • MF: GO:0008168 : methyltransferase activity : IEA
  • BP: GO:0006400 : tRNA modification : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • MF: GO:0008757 : S-adenosylmethionine-dependent methyltransferase activity : IEA
  • BP: GO:0002098 : tRNA wobble uridine modification : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • MF: GO:0016300 : tRNA (uracil) methyltransferase activity : IEA
Domain Structure from CDD
  • COG4976: Predicted methyltransferase (contains TPR repeat) [General function prediction only]
  • AdoMet_MTases: S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP0389iron-dependent superoxide dismutase
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)