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Gene HP1259 from Helicobacter pylori 26695: hypothetical protein
Member of NCBI Protein Clusters CLSK496431(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898880
UniProtKB accession
RefSeq Protein accession NP_208051.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1259
  • locus tag: HP1259
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction NAD-dependent deacetylase
Prof. David Horn 3.5.1: acting on C-N bonds in linear amides / (References: 20034383)
Prof. Vitkup 2.4.2.31 / Confidence:0.006 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0019904 protein domain specific binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043130 ubiquitin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042903 tubulin deacetylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0035035 histone acetyltransferase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0017136 NAD-dependent histone deacetylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003714 transcription corepressor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003956 NAD(P)+-protein-arginine ADP-ribosyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008022 protein C-terminus binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0046970 NAD-dependent histone deacetylase activity (H4-K16 specific) / (References: 19435885)
Berkeley Phylogenomics Group GO:0002039 p53 binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0045129 NAD-independent histone deacetylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0019213 deacetylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0046969 NAD-dependent histone deacetylase activity (H3-K9 specific) / (References: 19435885)
Berkeley Phylogenomics Group GO:0042826 histone deacetylase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019899 enzyme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042393 histone binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008134 transcription factor binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0070403 NAD binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003950 NAD+ ADP-ribosyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0032041 NAD-dependent histone deacetylase activity (H3-K14 specific) / (References: 19435885)
Berkeley Phylogenomics Group GO:0016564 transcription repressor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0016566 specific transcriptional repressor activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green cobB from Aggregatibacter actinomycetemcomitans

to see the rest 5 genes click here
GO terms
  • BP: GO:0006342 : chromatin silencing : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0070403 : NAD binding : IEA
  • BP: GO:0045449 : regulation of transcription : IEA
  • MF: GO:0008270 : zinc ion binding : IEA
  • BP: GO:0006476 : protein amino acid deacetylation : IEA
  • MF: GO:0016811 : hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides : IEA
Domain Structure from CDD
  • SIRT5_Af1_CobB: SIRT5_Af1_CobB: Eukaryotic, archaeal and prokaryotic group (class3) which includes human sirtuin SIRT5, Archaeoglobus fu.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
pyrEorotate phosphoribosyltransferase
 
HP1258hypothetical protein
 
HP1260NADH dehydrogenase subunit A
 
HP1261NADH dehydrogenase subunit B