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Gene HP0422 from Helicobacter pylori 26695: arginine decarboxylase
Member of NCBI Protein Clusters PRK05354(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898896
UniProtKB accession
RefSeq Protein accession NP_207220.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0422
  • locus tag: HP0422
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction arginine decarboxylase
Prof. Vitkup 4.1.1.19 / Confidence:0.128 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042978 ornithine decarboxylase activator activity / (References: 19435885)
Berkeley Phylogenomics Group 4.1.1.19: Arginine decarboxylase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0008836 diaminopimelate decarboxylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008792 arginine decarboxylase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004586 ornithine decarboxylase activity / (References: 19435885)
Berkeley Phylogenomics Group 4.1.1.20: Diaminopimelate decarboxylase. / (References: 19435885)
Berkeley Phylogenomics Group 4.1.1.17: Ornithine decarboxylase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0008073 ornithine decarboxylase inhibitor activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green speA from Escherichia coli str. K-12 substr. MG1655

to see the rest 3 genes click here
GO terms
  • MF: GO:0016829 : lyase activity : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • MF: GO:0008792 : arginine decarboxylase activity : IEA
  • BP: GO:0006527 : arginine catabolic process : IEA
  • BP: GO:0008295 : spermidine biosynthetic process : IEA
  • MF: GO:0016831 : carboxy-lyase activity : IEA
Domain Structure from CDD
  • PLPDE_III: Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzymes. This family includes eukaryotic D-serine dehydratases (DSD), cry.... (More)
  • PLPDE_III_ADC: Type III Pyridoxal 5-phosphate (PLP)-Dependent Enzyme Arginine Decarboxylase. This subfamily includes plants and biosynt.... (More)
  • speA: arginine decarboxylase, biosynthetic. A distinct biodegradative form is also pyridoxal phosphate-dependent but is not similar in sequence.

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
HP0420hypothetical protein
 
HP0421type 1 capsular polysaccharide biosynthesis protei
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ARGDC

Name
arginine decarboxylase
Formula
arg-DASH-L[c] + h[c] -> agm[c] + co2[c]
Pathway
Spermidine Biosynthesis

Metabolic Reaction: GLUDC

Name
Glutamate Decarboxylase
Formula
glu-DASH-L[c] + h[c] -> 4abut[c] + co2[c]
Pathway
Glutamate Metabolism

Source: Ported to COMBREX by Segre's Lab
KEGG