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Gene HP0392 from Helicobacter pylori 26695: histidine kinase (cheA)
Member of NCBI Protein Clusters CLSK872488(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898900
UniProtKB accession
RefSeq Protein accession NP_207190.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0392
  • locus tag: HP0392
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction chemotaxis protein CheA
Prof. Vitkup / Confidence:0.009 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0016772 transferase activity, transferring phosphorus-containing groups / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group Histidine kinase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0009927 histidine phosphotransfer kinase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green cheA from Bacillus subtilis subsp. subtilis str. 168
(%_identity=36.68; E_val=1e-118; BitScore=422.0)

other hits with E-value < 1e-05
GO terms
  • BP: GO:0000160 : two-component signal transduction system (phosphorelay) : IEA
  • MF: GO:0016772 : transferase activity, transferring phosphorus-containing groups : IEA
  • CC: GO:0005622 : intracellular : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0018106 : peptidyl-histidine phosphorylation : IEA
  • MF: GO:0016301 : kinase activity : IEA
  • BP: GO:0007165 : signal transduction : IEA
  • BP: GO:0016310 : phosphorylation : IEA
  • MF: GO:0004673 : protein histidine kinase activity : IEA
  • MF: GO:0000155 : two-component sensor activity : IEA
  • BP: GO:0006935 : chemotaxis : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000156 : two-component response regulator activity : IEA
  • BP: GO:0006355 : regulation of transcription, DNA-dependent : IEA
  • MF: GO:0004871 : signal transducer activity : IEA
Domain Structure from CDD
  • HPT: Histidine Phosphotransfer domain, involved in signalling through a two part component systems in which an autophosphoryl.... (More)
  • REC: Signal receiver domain; originally thought to be unique to bacteria (CheY, OmpR, NtrC, and PhoB), now recently identifie.... (More)
  • H-kinase_dim: Signal transducing histidine kinase, homodimeric domain. This helical bundle domain is the homodimer interface of the si.... (More)
  • HATPase_c: Histidine kinase-like ATPases; This family includes several ATP-binding proteins for example: histidine kinase, DNA gyra.... (More)
  • CheA_reg: CheA regulatory domain; CheA is a histidine protein kinase present in bacteria and archea. Activated by the chemotaxis r.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
domain fusion
HP0391purine-binding chemotaxis protein (cheW)
HP0394hypothetical protein
HP0393chemotaxis protein (cheV)
HP0019chemotaxis protein (cheV)  
HP0616chemotaxis protein (cheV)  
HP0103methyl-accepting chemotaxis protein (tlpB)  
HP0599hemolysin secretion protein precursor (hylB)  
HP0099methyl-accepting chemotaxis protein (tlpA)  
HP0082methyl-accepting chemotaxis transducer (tlpC)  
HP1067chemotaxis protein (cheY)