Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene gltX from Helicobacter pylori 26695: glutamyl-tRNA synthetase
Member of NCBI Protein Clusters PRK01406(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898901
UniProtKB accession
RefSeq Protein accession NP_207274.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: gltX
  • locus tag: HP0476
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction glutamyl-tRNA synthetase
Prof. Vitkup 6.1.1.17 / Confidence:0.564 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group 6.1.1.17: Glutamate--tRNA ligase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004819 glutamine-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004818 glutamate-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004827 proline-tRNA ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group 6.1.1.18: Glutamine--tRNA ligase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green gltX from Escherichia coli str. K-12 substr. MG1655
(%_identity=42.95; E_val=7e-103; BitScore=369.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green gltX from Thermosynechococcus elongatus BP-1

to see the rest 6 genes click here
GO terms
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016874 : ligase activity : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0004818 : glutamate-tRNA ligase activity : IEA
  • BP: GO:0006418 : tRNA aminoacylation for protein translation : IEA
  • BP: GO:0006424 : glutamyl-tRNA aminoacylation : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0004812 : aminoacyl-tRNA ligase activity : IEA
Domain Structure from CDD
  • gltX: glutamyl-tRNA synthetase; Reviewed
  • GluRS_core: catalytic core domain of descriminating glutamyl-tRNA synthetase. Descriminating Glutamyl-tRNA synthetase (GluRS) cataly.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Metabolic Annotation from Palsson Lab

Metabolic Reaction: GLUTRS

Name
Glutamyl-tRNA synthetase
Formula
atp[c] + glu-DASH-L[c] + trnaglu[c] -> amp[c] + glutrna[c] + ppi[c]
Pathway
Heme biosynthesis
Other Genes

Source: Ported to COMBREX by Segre's Lab
KEGG