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Gene HP0098 from Helicobacter pylori 26695: threonine synthase
Member of NCBI Protein Clusters PRK09225(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898925
UniProtKB accession
RefSeq Protein accession NP_206898.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0098
  • locus tag: HP0098
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction threonine synthase
Prof. Vitkup / Confidence:0.35 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0004795 threonine synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0030170 pyridoxal phosphate binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green ST1233 from Sulfolobus tokodaii str. 7

to see the rest 27 genes click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0006520 : cellular amino acid metabolic process : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
  • BP: GO:0008152 : metabolic process : IEA
  • BP: GO:0009088 : threonine biosynthetic process : IEA
  • MF: GO:0004795 : threonine synthase activity : IEA
  • MF: GO:0030170 : pyridoxal phosphate binding : IEA
Domain Structure from CDD
  • Thr-synth_2: Threonine synthase catalyzes the final step of threonine biosynthesis. The conversion of O-phosphohomoserine into threon.... (More)
  • ThrC: Threonine synthase [Amino acid transport and metabolism]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP0097hypothetical protein
trpDanthranilate phosphoribosyltransferase 
HP0822homoserine dehydrogenase 
HP1279bifunctional indole-3-glycerol phosphate synthase/ 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: THRS

threonine synthase
h2o[c] + phom[c] -> pi[c] + thr-DASH-L[c]
Lysine/ Threonine Biosynthesis

Source: Ported to COMBREX by Segre's Lab