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Gene HP0197 from Helicobacter pylori 26695: methionine adenosyltransferase
Member of NCBI Protein Clusters PRK05250(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898926
UniProtKB accession
RefSeq Protein accession NP_206996.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0197
  • locus tag: HP0197
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction S-adenosylmethionine synthetase
Prof. Vitkup 2.5.1.6 / Confidence:0.575 (References: 19935659, 16507154)
Berkeley Phylogenomics Group 2.5.1.6: Methionine adenosyltransferase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green metK from Escherichia coli str. K-12 substr. MG1655
(%_identity=61.97; E_val=6e-136; BitScore=478.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green metK from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0000287 : magnesium ion binding : IEA
  • BP: GO:0006730 : one-carbon metabolic process : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0004478 : methionine adenosyltransferase activity : IEA
  • MF: GO:0016740 : transferase activity : IEA
Domain Structure from CDD
  • S-AdoMet_synt_C: S-adenosylmethionine synthetase, C-terminal domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.
  • PRK05250: S-adenosylmethionine synthetase; Validated
  • S-AdoMet_synt_M: S-adenosylmethionine synthetase, central domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.
  • S-AdoMet_synt_N: S-adenosylmethionine synthetase, N-terminal domain. The three domains of S-adenosylmethionine synthetase have the same alpha+beta fold.

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
HP0195enoyl-(acyl carrier protein) reductase
 
  
lpxDUDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltra
 
  
HP0198nucleoside diphosphate kinase (ndk)
 
 
 
HP0199hypothetical protein
 
  
HP1337hypothetical protein  
 
HP0176fructose-bisphosphate aldolase  
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: METAT

Name
methionine adenosyltransferase
Formula
atp[c] + h2o[c] + met-DASH-L[c] -> amet[c] + pi[c] + ppi[c]
Pathway
Spermidine Biosynthesis

Source: Ported to COMBREX by Segre's Lab
KEGG
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)