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Gene HP0558 from Helicobacter pylori 26695: 3-oxoacyl-(acyl carrier protein) synthase II
Member of NCBI Protein Clusters PRK08439(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898935
UniProtKB accession
RefSeq Protein accession NP_207353.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0558
  • locus tag: HP0558
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction 3-oxoacyl-(acyl carrier protein) synthase II
Prof. Vitkup 2.3.1.41 / Confidence:0.595 (References: 19935659, 16507154)
Berkeley Phylogenomics Group 2.3.1.165: 6-methylsalicylic acid synthase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004315 3-oxoacyl-[acyl-carrier-protein] synthase activity / (References: 19435885)
Berkeley Phylogenomics Group 2.3.1.179: Beta-ketoacyl-acyl-carrier-protein synthase II. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group 2.3.1.41: Beta-ketoacyl-acyl-carrier-protein synthase I. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number 2.3.1.41 (See reaction via BRENDA)) (Source: NCBI RefSeq)
BLASTP hits to experimentally validated proteins
green fabF from Bacillus subtilis subsp. subtilis str. 168
(%_identity=49.15; E_val=4e-109; BitScore=389.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green pksF from Bacillus subtilis subsp. subtilis str. 168

to see the rest 4 genes click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0009058 : biosynthetic process : IEA
  • MF: GO:0016747 : transferase activity, transferring acyl groups other than amino-acyl groups : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • BP: GO:0006633 : fatty acid biosynthetic process : IEA
  • BP: GO:0008152 : metabolic process : IEA
Domain Structure from CDD
  • PRK08439: 3-oxoacyl-(acyl carrier protein) synthase II; Reviewed
  • KAS_I_II: Beta-ketoacyl-acyl carrier protein (ACP) synthase (KAS), type I and II. KASs are responsible for the elongation steps in.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
domain fusion
HP0556hypothetical protein
 
   
HP0557acetyl-CoA carboxylase carboxyltransferase subunit
 
 
  
HP0559acyl carrier protein (acpP)
 
   
miaAtRNA delta(2)-isopentenylpyrophosphate transferase  
 
 
HP0640poly(A) polymerase (papS)  
 
 
HP10367, 8-dihydro-6-hydroxymethylpterin-pyrophosphokina  
 
 
HP0166response regulator (ompR)  
 
 
HP1505riboflavin biosynthesis protein (ribG)  
 
 
aroKshikimate kinase  
 
 
HP1365response regulator  
 
 
HP0090acyl-carrier-protein S-malonyltransferase  
 
 
clpXATP-dependent protease ATP-binding subunit ClpX  
 
 
prfBpeptide chain release factor 2  
 
 
HP1213polynucleotide phosphorylase/polyadenylase  
 
 
HP0683UDP-N-acetylglucosamine pyrophosphorylase (glmU)  
 
 
rpsA30S ribosomal protein S1  
 
 
HP1043response regulator  
 
 
HP1045acetyl-CoA synthetase   
 
HP05988-amino-7-oxononanoate synthase   
 
HP0976adenosylmethionine--8-amino-7-oxononanoate transam   
 
HP0306glutamate-1-semialdehyde aminotransferase   
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: C140SN

Name
Fatty acid biosynthesis (n-C14:0)
Formula
actACP[c] + 17 h[c] + 5 malACP[c] + 12 nadph[c] -> 5 ACP[c] + 5 co2[c] + 6 h2o[c] + myrsACP[c] + 12 nadp[c]
Pathway
Fatty Acid Synthesis
Other Genes

Metabolic Reaction: C160SN

Name
Fatty acid biosynthesis (n-C16:0)
Formula
actACP[c] + 20 h[c] + 6 malACP[c] + 14 nadph[c] -> 6 ACP[c] + 6 co2[c] + 7 h2o[c] + 14 nadp[c] + palmACP[c]
Pathway
Fatty Acid Synthesis
Other Genes

Metabolic Reaction: C180SN

Name
Fatty acid biosynthesis (n-C18:0)
Formula
actACP[c] + 23 h[c] + 7 malACP[c] + 16 nadph[c] -> 7 ACP[c] + 7 co2[c] + 8 h2o[c] + 16 nadp[c] + ocdcaACP[c]
Pathway
Fatty Acid Synthesis
Other Genes

Metabolic Reaction: C181SN

Name
Fatty acid biosynthesis (n-C18:1)
Formula
actACP[c] + 22 h[c] + 7 malACP[c] + 15 nadph[c] -> 7 ACP[c] + 7 co2[c] + 8 h2o[c] + 15 nadp[c] + octeACP[c]
Pathway
Fatty Acid Synthesis
Other Genes

Metabolic Reaction: C190cSN

Name
C190cSN
Formula
amet[c] + octeACP[c] -> ahcys[c] + c190cACP[c] + h[c]
Pathway
Fatty Acid Synthesis
Other Genes

Metabolic Reaction: KAS14

Name
beta-ketoacyl-ACP synthase
Formula
acACP[c] + h[c] + malACP[c] -> ACP[c] + actACP[c] + co2[c]
Pathway
Fatty Acid Synthesis

Metabolic Reaction: KAS_HP2

Name
3-hydroxy-octadecanoyl-ACP synthesis
Formula
2 h[c] + malACP[c] + nadph[c] + palmACP[c] -> 3hoctaACP[c] + ACP[c] + co2[c] + nadp[c]
Pathway
Fatty Acid Synthesis
Other Genes

Source: Ported to COMBREX by Segre's Lab
KEGG