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Gene HP0652 from Helicobacter pylori 26695: phosphoserine phosphatase (serB)
Member of NCBI Protein Clusters CLSK496141(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898951
UniProtKB accession
RefSeq Protein accession NP_207446.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0652
  • locus tag: HP0652
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 3M1Y
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction phosphoserine phosphatase
Prof. Vitkup / Confidence:0.662 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0050308 sugar-phosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008967 phosphoglycolate phosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0016773 phosphotransferase activity, alcohol group as acceptor / (References: 19435885)
Berkeley Phylogenomics Group GO:0000287 magnesium ion binding / (References: 19435885)
Berkeley Phylogenomics Group 5'-nucleotidase. / (References: 19435885)
Berkeley Phylogenomics Group Phosphoglycolate phosphatase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0004647 phosphoserine phosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group Phosphoserine phosphatase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0033883 pyridoxal phosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0031404 chloride ion binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
blue phnX from Pseudomonas aeruginosa LESB58

to see the rest 27 genes click here
GO terms
  • MF: GO:0016791 : phosphatase activity : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0006564 : L-serine biosynthetic process : IEA
  • MF: GO:0004647 : phosphoserine phosphatase activity : IEA
  • BP: GO:0008152 : metabolic process : IEA
Domain Structure from CDD
  • HAD_like: Haloacid dehalogenase-like hydrolases. The haloacid dehalogenase-like (HAD) superfamily includes L-2-haloacid dehalogena.... (More)
  • Hydrolase: haloacid dehalogenase-like hydrolase. This family are structurally different from the alpha/ beta hydrolase family (pfam.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP0653nonheme iron-containing ferritin (pfr)
Metabolic Annotation from Palsson Lab

Metabolic Reaction: PSP_D

phosphoserine phosphatase (D-serine)
h2o[c] + pser-DASH-D[c] -> pi[c] + ser-DASH-D[c]
Ser, Gly Biosynthesis

Metabolic Reaction: PSP_L

phosphoserine phosphatase (L-serine)
h2o[c] + pser-DASH-L[c] -> pi[c] + ser-DASH-L[c]
Ser, Gly Biosynthesis

Source: Ported to COMBREX by Segre's Lab