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Gene HP0221 from Helicobacter pylori 26695: nifU-like protein
Member of NCBI Protein Clusters CLSK872302(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898958
UniProtKB accession
RefSeq Protein accession NP_207019.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0221
  • locus tag: HP0221
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction NifU family protein
Berkeley Phylogenomics Group GO:0051539 4 iron, 4 sulfur cluster binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0032947 protein complex scaffold / (References: 19435885)
Berkeley Phylogenomics Group GO:0008198 ferrous iron binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0051537 2 iron, 2 sulfur cluster binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0050660 FAD binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0020037 heme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0050661 NADP or NADPH binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005506 iron ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005507 copper ion binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
GO terms
  • BP: GO:0016226 : iron-sulfur cluster assembly : IEA
  • MF: GO:0005506 : iron ion binding : IEA
  • MF: GO:0051536 : iron-sulfur cluster binding : IEA
Domain Structure from CDD
  • Fer2_BFD: BFD-like [2Fe-2S] binding domain. bacterioferritin-associated ferredoxin; Provisional
  • NifU_proper: Fe-S cluster assembly protein NifU. Three different but partially homologous Fe-S cluster assembly systems have been des.... (More)
  • NifU: NifU-like domain. Thioredoxin-like proteins and domains [Posttranslational modification, protein turnover, chaperones]
  • IscU_like: Iron-sulfur cluster scaffold-like proteins. IscU_like and NifU_like proteins. IscU and NifU function as a scaffold for t.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
HP0219hypothetical protein
HP0220cysteine desulfurase
HP0223DNA repair protein RadA
HP0222hypothetical protein
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)