Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene aroK from Helicobacter pylori 26695: shikimate kinase
Member of NCBI Protein Clusters PRK00131(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898985
UniProtKB accession
RefSeq Protein accession NP_206956.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: aroK
  • locus tag: HP0157
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction shikimate kinase
Prof. Vitkup 2.7.1.71 / Confidence:0.867 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004764 shikimate 5-dehydrogenase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0046316 gluconokinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003866 3-phosphoshikimate 1-carboxyvinyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004765 shikimate kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003677 DNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003855 3-dehydroquinate dehydratase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003856 3-dehydroquinate synthase activity / (References: 19435885)
Source References Functional description
GSDB Under Review shikimate kinase (source organism: Helicobacter pylori; strain specific ID: NCBI_TaxID=210)
Functional Status greenGreen (experimental evidence, uncurated)
EC number
GO terms
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
  • MF: GO:0004765 : shikimate kinase activity : IEA
  • MF: GO:0016301 : kinase activity : IEA
  • BP: GO:0009073 : aromatic amino acid family biosynthetic process : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0000287 : magnesium ion binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • aroK: shikimate kinase; Reviewed
  • SK: Shikimate kinase (SK) is the fifth enzyme in the shikimate pathway, a seven-step biosynthetic pathway which converts ery.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
aroK (6)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
domain fusion
HP0155hypothetical protein
 
  
HP0156hypothetical protein
 
  
HP0158hypothetical protein
 
  
HP1574riboflavin synthase subunit alpha 
 
 
HP05583-oxoacyl-(acyl carrier protein) synthase II 
 
 
HP10367, 8-dihydro-6-hydroxymethylpterin-pyrophosphokina 
 
 
HP1510hypothetical protein 
 
 
HP1505riboflavin biosynthesis protein (ribG) 
 
 
aroB3-dehydroquinate synthase  
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: SHKK

Name
shikimate kinase
Formula
atp[c] + skm[c] -> adp[c] + h[c] + skm5p[c]
Pathway
Chorismate Biosynthesis

Source: Ported to COMBREX by Segre's Lab
KEGG
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)