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Gene HP0663 from Helicobacter pylori 26695: chorismate synthase
Member of NCBI Protein Clusters PRK05382(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 898986
UniProtKB accession
RefSeq Protein accession NP_207457.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0663
  • locus tag: HP0663
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 1UM0 1UMF
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction chorismate synthase
Prof. Vitkup / Confidence:0.968 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green aroC from Escherichia coli str. K-12 substr. MG1655
(%_identity=45.98; E_val=3e-79; BitScore=290.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green aroC from Staphylococcus aureus

to see the rest 3 genes click here
GO terms
  • MF: GO:0004107 : chorismate synthase activity : IEA
  • MF: GO:0016829 : lyase activity : IEA
  • BP: GO:0009073 : aromatic amino acid family biosynthetic process : IEA
  • BP: GO:0008652 : cellular amino acid biosynthetic process : IEA
Domain Structure from CDD
  • Chorismate_synthase: Chorismase synthase, the enzyme catalyzing the final step of the shikimate pathway. Chorismate synthase (CS; 5-enolpyruv.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
rnhAribonuclease H
rncribonuclease III
HP0665coproporphyrinogen III oxidase
HP0664hypothetical protein
aroEshikimate 5-dehydrogenase 
HP04013-phosphoshikimate 1-carboxyvinyltransferase 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: CHORS

chorismate synthase
3psme[c] -> chor[c] + pi[c]
Chorismate Biosynthesis

Source: Ported to COMBREX by Segre's Lab
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)