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Gene rnc from Helicobacter pylori 26695: ribonuclease III

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Summary
Member of NCBI Protein Clusters PRK00102(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899029
UniProtKB accession
RefSeq Protein accession NP_207456.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: rnc
  • locus tag: HP0662
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)

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Actions You Can Take
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).

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Function Predictions
Source Predicted function(s)
NCBI Protein Cluster Prediction ribonuclease III
Berkeley Phylogenomics Group GO:0003723 RNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0050733 RS domain binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0048027 mRNA 5'-UTR binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0035197 siRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042803 protein homodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008157 protein phosphatase 1 binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003730 mRNA 3'-UTR binding / (References: 19435885)
Berkeley Phylogenomics Group 3.1.26.3: Ribonuclease III. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003725 double-stranded RNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0035198 miRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003682 chromatin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004647 phosphoserine phosphatase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003726 double-stranded RNA adenosine deaminase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004131 cytosine deaminase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0010843 promoter binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003735 structural constituent of ribosome / (References: 19435885)
Berkeley Phylogenomics Group GO:0004525 ribonuclease III activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0016563 transcription activator activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0017151 DEAD/H-box RNA helicase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003727 single-stranded RNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003729 mRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0016564 transcription repressor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003677 DNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0016443 bidentate ribonuclease III activity / (References: 19435885)

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Supporting Functional Information
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green rnc from Escherichia coli str. K-12 substr. MG1655
(%_identity=37.33; E_val=3e-32; BitScore=133.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green rnc from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • BP: GO:0016075 : rRNA catabolic process : IEA
  • BP: GO:0006397 : mRNA processing : IEA
  • CC: GO:0005622 : intracellular : IEA
  • MF: GO:0003725 : double-stranded RNA binding : IEA
  • MF: GO:0003723 : RNA binding : IEA
  • MF: GO:0004518 : nuclease activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0006364 : rRNA processing : IEA
  • MF: GO:0004525 : ribonuclease III activity : IEA
  • MF: GO:0004519 : endonuclease activity : IEA
  • BP: GO:0006396 : RNA processing : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • DSRM: Double-stranded RNA binding motif. Binding is not sequence specific but is highly specific for double stranded RNA. Foun.... (More)
  • rnc: ribonuclease III; Reviewed
  • RIBOc: RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RN.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database

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Functionally Linked Genes
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
HP0663chorismate synthase
 
 
HP0660hypothetical protein
 
 
rnhAribonuclease H
 
 
HP0664hypothetical protein
 
 
HP0962acyl carrier protein (acpP) 
 
fmtmethionyl-tRNA formyltransferase 
 
rpmA50S ribosomal protein L27 
 
obgEGTPase ObgE 
 
HP0559acyl carrier protein (acpP) 
 
tsfelongation factor Ts 
 
mnmAtRNA-specific 2-thiouridylase MnmA 
 
HP0956hypothetical protein 
 
HP1069cell division protein (ftsH) 
 
frrribosome recycling factor 
 
rplS50S ribosomal protein L19 
 
HP0013hypothetical protein 
 
HP0347hypothetical protein 
 
rpsP30S ribosomal protein S16 
 
tufelongation factor Tu 
 
rpsR30S ribosomal protein S18 
 
HP1245single-stranded DNA-binding protein 
 
rpsF30S ribosomal protein S6 
 
rpmG50S ribosomal protein L33 
 
prfApeptide chain release factor 1 
 
HP1497peptidyl-tRNA hydrolase 
 
HP0355GTP-binding protein LepA 
 
aspSaspartyl-tRNA synthetase 
 
rplQ50S ribosomal protein L17 
 
HP0745hypothetical protein 
 
HP1450putative inner membrane protein translocase compon 
 
rplI50S ribosomal protein L9 
 
HP0286cell division protein (ftsH) 
 
rpmI50S ribosomal protein L35 
 
rplL50S ribosomal protein L7/L12 
 

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Phenotype data
Phenotype Description Expression
Class		 Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)