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Gene HP0110 from Helicobacter pylori 26695: co-chaperone and heat shock protein (grpE)
Member of NCBI Protein Clusters PRK14149(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899121
UniProtKB accession
RefSeq Protein accession NP_206910.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0110
  • locus tag: HP0110
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction heat shock protein GrpE
Berkeley Phylogenomics Group GO:0000774 adenyl-nucleotide exchange factor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005507 copper ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0051082 unfolded protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
green grpE from Bacillus subtilis subsp. subtilis str. 168

to see the rest 2 gene click here
GO terms
  • CC: GO:0005737 : cytoplasm : IEA
  • CC: GO:0005739 : mitochondrion : IEA
  • BP: GO:0030150 : protein import into mitochondrial matrix : IEA
  • MF: GO:0051087 : chaperone binding : IEA
  • MF: GO:0005515 : protein binding : IEA
  • MF: GO:0042803 : protein homodimerization activity : IEA
  • MF: GO:0000774 : adenyl-nucleotide exchange factor activity : IEA
  • BP: GO:0006457 : protein folding : IEA
  • BP: GO:0006950 : response to stress : IEA
Domain Structure from CDD
  • GrpE: GrpE is the adenine nucleotide exchange factor of DnaK (Hsp70)-type ATPases. The GrpE dimer binds to the ATPase domain o.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
gene neighbourhoods
phylogenetic profile
dnaKmolecular chaperone DnaK
HP0111heat-inducible transcription repressor
HP0911rep helicase, single-stranded DNA-dependent ATPase  
HP1478DNA helicase II (uvrD)  
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)