Combrex Enter Keyword, gene symbol, or identifier (more options; Help )
Enter species name
Gene functional status (select)
Phenotype association (select)[View list of phenotypes]
Check to restrict search to:
Genes in Category A-C and Emerging/Re-Emerging pathogens
Genes in curated Protein Clusters
Genes with predictions submitted to COMBREX
P
Genes with solved structures in PDB
S
Genes with Pfam domains shared with human proteins
H
Genes with products purified by PSI
U
Genes cloned by PSI
C
close options

 

Gene adk from Helicobacter pylori 26695: adenylate kinase
Member of NCBI Protein Clusters PRK00279(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899292
UniProtKB accession
RefSeq Protein accession NP_207413.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: adk
  • locus tag: HP0618
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction adenylate kinase
Prof. Vitkup 2.7.4.3 / Confidence:0.812 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0016208 AMP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004017 adenylate kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0009041 uridylate kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0000287 magnesium ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004127 cytidylate kinase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0019206 nucleoside kinase activity / (References: 19435885)
Berkeley Phylogenomics Group 2.7.4.3: Adenylate kinase. / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green adk from Geobacillus stearothermophilus
(%_identity=28.64; E_val=2e-19; BitScore=90.9)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green kad from Aquifex aeolicus VF5

to see the rest 3 genes click here
GO terms
  • MF: GO:0005524 : ATP binding : IEA
  • MF: GO:0016301 : kinase activity : IEA
  • MF: GO:0019205 : nucleobase, nucleoside, nucleotide kinase activity : IEA
  • BP: GO:0006139 : nucleobase, nucleoside, nucleotide and nucleic acid metabolic process : IEA
  • MF: GO:0004017 : adenylate kinase activity : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • BP: GO:0009165 : nucleotide biosynthetic process : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
Domain Structure from CDD
  • adk: adenylate kinase; Reviewed
  • ADK: Adenylate kinase (ADK) catalyzes the reversible phosphoryl transfer from adenosine triphosphates (ATP) to adenosine mono.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
HP0616chemotaxis protein (cheV)
 
aspSaspartyl-tRNA synthetase
 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: ADK1

Name
adenylate kinase
Formula
amp[c] + atp[c] <=> 2 adp[c]
Pathway
ATP de novo Synthesis

Metabolic Reaction: DADK

Name
deoxyadenylate kinase
Formula
atp[c] + damp[c] <=> adp[c] + dadp[c]
Pathway
Nucleotide Interconversion

Source: Ported to COMBREX by Segre's Lab
KEGG