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Gene HP0665 from Helicobacter pylori 26695: coproporphyrinogen III oxidase
Member of NCBI Protein Clusters PRK09249(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899306
UniProtKB accession
RefSeq Protein accession NP_207459.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP0665
  • locus tag: HP0665
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction coproporphyrinogen III oxidase
Prof. David Horn coproporphyrinogen dehydrogenase / (References: 20034383)
Prof. Vitkup / Confidence:0.71 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0051989 coproporphyrinogen dehydrogenase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0051539 4 iron, 4 sulfur cluster binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: BRENDA)
BLASTP hits to experimentally validated proteins
green hemN from Escherichia coli str. K-12 substr. MG1655
(%_identity=42.3; E_val=1e-107; BitScore=385.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green hemN from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • BP: GO:0055114 : oxidation reduction : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0006779 : porphyrin biosynthetic process : IEA
  • MF: GO:0051536 : iron-sulfur cluster binding : IEA
  • MF: GO:0051539 : 4 iron, 4 sulfur cluster binding : IEA
  • MF: GO:0016491 : oxidoreductase activity : IEA
  • MF: GO:0004109 : coproporphyrinogen oxidase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • MF: GO:0051989 : coproporphyrinogen dehydrogenase activity : IEA
Domain Structure from CDD
  • hemN: oxygen-independent coproporphyrinogen III oxidase. This model represents HemN, the oxygen-independent coproporphyrinogen.... (More)
  • HemN_C: HemN C-terminal region. Members of this family are all oxygen-independent coproporphyrinogen-III oxidases (HemN). This e.... (More)
  • Radical_SAM: Radical SAM superfamily. Enzymes of this family generate radicals by combining a 4Fe-4S cluster and S-adenosylmethionine.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP0666glycerol-3-phosphate dehydrogenase
HP0663chorismate synthase
HP0664hypothetical protein
HP1556cell division protein (ftsI) 
clpXATP-dependent protease ATP-binding subunit ClpX 
HP0743rod shape-determining protein (mreB) 
HP1560cell division protein (ftsW) 
HP0648UDP-N-acetylglucosamine 1-carboxyvinyltransferase 
murBUDP-N-acetylenolpyruvoylglucosamine reductase 
HP0223DNA repair protein RadA 
HP0387primosome assembly protein PriA 
HP1459hypothetical protein 
HP1565penicillin-binding protein 2 (pbp2) 
clpPATP-dependent Clp protease proteolytic subunit 
murCUDP-N-acetylmuramate--L-alanine ligase 
HP1541transcription-repair coupling factor (trcF) 
secGpreprotein translocase subunit SecG 
Metabolic Annotation from Palsson Lab

Metabolic Reaction: CPPPGO

coproporphyrinogen oxidase (O2 required)
cpppg3[c] + 2 h[c] + o2[c] -> 2 co2[c] + 2 h2o[c] + pppg9[c]
Heme biosynthesis
Other Genes

Source: Ported to COMBREX by Segre's Lab