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Gene HP1069 from Helicobacter pylori 26695: cell division protein (ftsH)
Member of NCBI Protein Clusters CLSK872348(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899605
UniProtKB accession
RefSeq Protein accession NP_207860.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1069
  • locus tag: HP1069
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB: 2R62 2R65
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction cell division protein FtsH
Prof. David Horn 3.4.24: metalloendopeptidases / (References: 20034383)
Prof. Vitkup 3.6.4.3 / Confidence:0.044 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0042623 ATPase activity, coupled / (References: 19435885)
Berkeley Phylogenomics Group GO:0043014 alpha-tubulin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005524 ATP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0004222 metalloendopeptidase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0003777 microtubule motor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0000287 magnesium ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019904 protein domain specific binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0032403 protein complex binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0031593 polyubiquitin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019905 syntaxin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0010843 promoter binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019903 protein phosphatase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0017048 Rho GTPase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005516 calmodulin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0016887 ATPase activity / (References: 19435885)
Berkeley Phylogenomics Group 3.6.4.3: Microtubule-severing ATPase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0008568 microtubule-severing ATPase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0046982 protein heterodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004175 endopeptidase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019901 protein kinase binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008022 protein C-terminus binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0045502 dynein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0048487 beta-tubulin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008270 zinc ion binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008017 microtubule binding / (References: 19435885)
Source References Functional description
GSDB Under Review cell division protease ftsH homolog (source organism: Helicobacter pylori; strain specific ID: NCBI_TaxID=210)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0046872 : metal ion binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0007049 : cell cycle : IEA
  • BP: GO:0030163 : protein catabolic process : IEA
  • BP: GO:0006508 : proteolysis : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • MF: GO:0008237 : metallopeptidase activity : IEA
  • MF: GO:0017111 : nucleoside-triphosphatase activity : IEA
  • CC: GO:0016020 : membrane : IEA
  • BP: GO:0051301 : cell division : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0004222 : metalloendopeptidase activity : IEA
  • MF: GO:0008233 : peptidase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • Peptidase_M41: Peptidase family M41.
  • AAA: The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPa.... (More)
  • FtsH_fam: ATP-dependent metalloprotease FtsH. HflB(FtsH) is a pleiotropic protein required for correct cell division in bacteria. .... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
ftsH , ftsH_2 , ftsH-2 (2) , HPAG1_0378 , HPSH_01975
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
phylogenetic profile
HP1067chemotaxis protein (cheY)
 
 
prmAribosomal protein L11 methyltransferase
 
 
HP1070hypothetical protein
 
 
HP1071phosphatidylserine synthase (pssA)
 
 
fmtmethionyl-tRNA formyltransferase 
 
rpmA50S ribosomal protein L27 
 
obgEGTPase ObgE 
 
aspSaspartyl-tRNA synthetase 
 
rplQ50S ribosomal protein L17 
 
HP0745hypothetical protein 
 
HP0559acyl carrier protein (acpP) 
 
tsfelongation factor Ts 
 
mnmAtRNA-specific 2-thiouridylase MnmA 
 
HP0956hypothetical protein 
 
HP0962acyl carrier protein (acpP) 
 
rncribonuclease III 
 
rplS50S ribosomal protein L19 
 
frrribosome recycling factor 
 
HP0013hypothetical protein 
 
HP0347hypothetical protein 
 
rpsP30S ribosomal protein S16 
 
tufelongation factor Tu 
 
rpsR30S ribosomal protein S18 
 
HP1245single-stranded DNA-binding protein 
 
rpsF30S ribosomal protein S6 
 
rpmG50S ribosomal protein L33 
 
prfApeptide chain release factor 1 
 
HP1497peptidyl-tRNA hydrolase 
 
HP0355GTP-binding protein LepA 
 
HP1450putative inner membrane protein translocase compon 
 
rplI50S ribosomal protein L9 
 
rpmI50S ribosomal protein L35 
 
rplL50S ribosomal protein L7/L12 
 
Phenotype Description Expression
Class
Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)