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Gene HP1071 from Helicobacter pylori 26695: phosphatidylserine synthase (pssA)
Member of NCBI Protein Clusters CLSK872347(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899607
UniProtKB accession
RefSeq Protein accession NP_207862.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1071
  • locus tag: HP1071
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction CDP-diacylglycerol--serine O-phosphatidyltransferase
Prof. Vitkup / Confidence:0.931 (References: 19935659, 16507154)
Berkeley Phylogenomics Group Phosphatidylcholine synthase. / (References: 19435885)
Berkeley Phylogenomics Group Diacylglycerol cholinephosphotransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0030145 manganese ion binding / (References: 19435885)
Berkeley Phylogenomics Group Ethanolaminephosphotransferase. / (References: 19435885)
Berkeley Phylogenomics Group CDP-diacylglycerol--inositol 3-phosphatidyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019992 diacylglycerol binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005529 sugar binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0008444 CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0008808 cardiolipin synthase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004142 diacylglycerol cholinephosphotransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004307 ethanolaminephosphotransferase activity / (References: 19435885)
Berkeley Phylogenomics Group CDP-diacylglycerol--serine O-phosphatidyltransferase. / (References: 19435885)
Berkeley Phylogenomics Group GO:0003882 CDP-diacylglycerol-serine O-phosphatidyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003881 CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0043178 alcohol binding / (References: 19435885)
Source References Functional description
GSDB Under Review CDP-diacylglycerol--serine O-phosphatidyltransferase (source organism: Helicobacter pylori; strain specific ID: NCBI_TaxID=210)
Functional Status greenGreen (experimental evidence, uncurated)
EC number (See reaction via BRENDA)) (Source: BRENDA)
GO terms
  • MF: GO:0016780 : phosphotransferase activity, for other substituted phosphate groups : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • BP: GO:0046341 : CDP-diacylglycerol metabolic process : IEA
  • MF: GO:0003882 : CDP-diacylglycerol-serine O-phosphatidyltransferase activity : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • BP: GO:0008654 : phospholipid biosynthetic process : IEA
  • MF: GO:0016740 : transferase activity : IEA
  • CC: GO:0016020 : membrane : IEA
Domain Structure from CDD
  • CDP-OH_P_transf: CDP-alcohol phosphatidyltransferase. phosphatidylglycerophosphate synthetase; Provisional
  • PssA: Phosphatidylserine synthase [Lipid metabolism]

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
HPAG1_0376 , HPSH_01970 , pssA (4)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP1069cell division protein (ftsH)
HP1070hypothetical protein
HP1072copper-transporting ATPase, P-type (copA)
HP1073copper ion binding protein (copP)
Metabolic Annotation from Palsson Lab

Metabolic Reaction: PSSA_HP

Phosphatidylserine synthase Hp specific
cdpdag-HP[c] + ser-DASH-L[c] <=> cmp[c] + h[c] + ps-HP[c]
Glycerolipid Synthesis

Source: Ported to COMBREX by Segre's Lab