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Gene HP1077 from Helicobacter pylori 26695: nickel transport protein (nixA)
Member of NCBI Protein Clusters CLSK872344(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899613
UniProtKB accession
RefSeq Protein accession NP_207868.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1077
  • locus tag: HP1077
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:
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Source Predicted function(s)
NCBI Protein Cluster Prediction high affinity nickel transport protein
Berkeley Phylogenomics Group GO:0015099 nickel ion transmembrane transporter activity / (References: 19435885)
Source References Functional description
GSDB Under Review high-affinity nickel-transport protein nixA (source organism: Helicobacter pylori; strain specific ID: NCBI_TaxID=210)
Functional Status greenGreen (experimental evidence, uncurated)
GO terms
  • MF: GO:0015099 : nickel ion transmembrane transporter activity : IEA
  • MF: GO:0046872 : metal ion binding : IEA
  • BP: GO:0030001 : metal ion transport : IEA
  • BP: GO:0006810 : transport : IEA
  • CC: GO:0016021 : integral to membrane : IEA
  • CC: GO:0005886 : plasma membrane : IEA
  • BP: GO:0015675 : nickel ion transport : IEA
  • BP: GO:0055085 : transmembrane transport : IEA
  • CC: GO:0016020 : membrane : IEA
Domain Structure from CDD
  • NicO: High-affinity nickel-transport protein. nickel/cobalt efflux protein RcnA; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
Based on the function of this gene, COMBREX predictions were made to the following related genes (mouse over gene symbol for details) [Download ]
Hac_1190 , HPAG1_0370 , HPSH_01930 , nixA (3)
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP1078hypothetical protein
HP1079hypothetical protein
Metabolic Annotation from Palsson Lab

Metabolic Reaction: NIabc

nickel transport via ABC system
atp[c] + h2o[c] + ni2[e] -> adp[c] + h[c] + ni2[c] + pi[c]
Transport, ABC system
Other Genes

Source: Ported to COMBREX by Segre's Lab