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Gene HP1140 from Helicobacter pylori 26695: biotin--protein ligase
Member of NCBI Protein Clusters PRK08477(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899677
UniProtKB accession
RefSeq Protein accession NP_207931.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1140
  • locus tag: HP1140
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Source Predicted function(s)
NCBI Protein Cluster Prediction biotin--protein ligase
Prof. Vitkup / Confidence:0.43 (References: 19935659, 16507154)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0016564 transcription repressor activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004080 biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0004077 biotin-[acetyl-CoA-carboxylase] ligase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0009374 biotin binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019899 enzyme binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003677 DNA binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number (See reaction via BRENDA)) (Source: NCBI RefSeq)
BLASTP hits to experimentally validated proteins This gene does not have a BLAST match to any experimentally validated gene with an E value below 1e-5
Share the same Pfam domain composition with the following experimentally validated proteins
blue lipB from Mycobacterium tuberculosis CDC1551

to see the rest 3 genes click here
GO terms
  • MF: GO:0003824 : catalytic activity : IEA
  • BP: GO:0006464 : protein modification process : IEA
  • MF: GO:0004077 : biotin-[acetyl-CoA-carboxylase] ligase activity : IEA
Domain Structure from CDD
  • PRK08477: biotin--protein ligase; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
HP1138plasmid replication-partition related protein
HP1139SpoOJ regulator (soj)
fmtmethionyl-tRNA formyltransferase
HP1142hypothetical protein
Metabolic Annotation from Palsson Lab

Metabolic Reaction: BACCL

biotin-[acetyl-CoA-carboxylase] ligase
atp[c] + btn[c] + h[c] -> btamp[c] + ppi[c]
Biotin Biosynthesis

Source: Ported to COMBREX by Segre's Lab