Gene HP1497 from Helicobacter pylori 26695: peptidyl-tRNA hydrolase
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Member of NCBI Protein Clusters
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PRK05426(See COMBREX Page ) (See NCBI page)
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NCBI Entrez GeneID
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899794
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UniProtKB accession
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RefSeq Protein accession
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NP_208288.1 (PROVISIONAL)
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Gene Symbol(s)
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- symbol: HP1497
- locus tag: HP1497
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Organism
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Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Other Cross References:
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S Structure(s) available in PDB:
C Gene cloned by a participant in the Protein Structure Initiative (PSI):
TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
U Protein purified by a participant in the Protein Structure Initiative (PSI):
TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
- Protein described in EcoCyc:
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Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to
check the list of current predicted functions in the section immediately below beforehand.
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Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally
validated) (info).
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Post a comment about this gene to appear on this page (info).
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Functional Status
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blue (function predicted, no experimental evidence)
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Source of prediction
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NCBI Protein Clusters info
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EC number
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BLASTP hits to experimentally validated proteins
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other hits with E-value < 1e-05
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Share the same Pfam domain composition with the following experimentally validated proteins
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to see the rest 2 gene click here
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GO terms
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MF:
GO:0004045 : aminoacyl-tRNA hydrolase activity : IEA
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CC:
GO:0005737 : cytoplasm : IEA
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BP:
GO:0006412 : translation : IEA
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MF:
GO:0016787 : hydrolase activity : IEA
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Domain Structure from CDD
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- PTH: Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA when peptidyl-tRNA is released prematurely from the ribosome. This ensures the recycling of peptidyl-tRNAs into tRNAs produced through abortion of translation and is essential for cell viability.This group also contains chloroplast RNA splicing 2 (CRS2), which is closely related nuclear-encoded protein required for the splicing of nine group II introns in chloroplasts..... (More)
See domain structure on NCBI Conserved Domain Database
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Domain structure from Pfam
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See domain structure on Pfam Database
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The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page,
as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB).
(Info.)
These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table.
Note: VisANT requires Java. To install the latest version of Java, see www.java.com
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 | HP1499 | hypothetical protein | | | | HP1498 | hypothetical protein | | | | HP1495 | transaldolase | | | | HP1496 | 50S ribosomal protein L25/general stress protein C | | | | frr | ribosome recycling factor | | | | HP0355 | GTP-binding protein LepA | | | | HP1245 | single-stranded DNA-binding protein | | | | HP0956 | hypothetical protein | | | | obgE | GTPase ObgE | | | | prfA | peptide chain release factor 1 | | | | HP0559 | acyl carrier protein (acpP) | | | | rpmI | 50S ribosomal protein L35 | | | | rplI | 50S ribosomal protein L9 | | | | tuf | elongation factor Tu | | | | HP0013 | hypothetical protein | | | | mnmA | tRNA-specific 2-thiouridylase MnmA | | | | rpsP | 30S ribosomal protein S16 | | | | HP0286 | cell division protein (ftsH) | | | | fmt | methionyl-tRNA formyltransferase | | | | rpsF | 30S ribosomal protein S6 | | | | aspS | aspartyl-tRNA synthetase | | | | rplQ | 50S ribosomal protein L17 | | | | HP0745 | hypothetical protein | | | | tsf | elongation factor Ts | | | | HP0962 | acyl carrier protein (acpP) | | | | rnc | ribonuclease III | | | | rplS | 50S ribosomal protein L19 | | | | HP1069 | cell division protein (ftsH) | | | | rpsR | 30S ribosomal protein S18 | | | | rplL | 50S ribosomal protein L7/L12 | | | | HP0347 | hypothetical protein | | | | rpmA | 50S ribosomal protein L27 | | | | HP1450 | putative inner membrane protein translocase compon | | | | rpmG | 50S ribosomal protein L33 | | | |
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Phenotype |
Description |
Expression Class |
Reference(s) |
Candidate essential gene |
Identified as essential gene in one or more studies (see references) |
Knock out |
(candidate essential)
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