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Gene HP1497 from Helicobacter pylori 26695: peptidyl-tRNA hydrolase

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Summary
Member of NCBI Protein Clusters PRK05426(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899794
UniProtKB accession
RefSeq Protein accession NP_208288.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1497
  • locus tag: HP1497
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
Other Cross References:
  • S
    Structure(s) available in PDB:
  • C
    Gene cloned by a participant in the Protein Structure Initiative (PSI): TargetDB. (To obtain a clone, please contact the PSI:Biology-Materials Repository.)
  • U
    Protein purified by a participant in the Protein Structure Initiative (PSI): TargetDB. (If you are interested in collaborating to obtain the protein, please contact the Northeast Structural Genomics consortium).
  • Protein described in EcoCyc:

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Actions You Can Take
Initiate the grant application process for experimentally validating this gene (Important notice about COMBREX grants.)
Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
Nominate this gene for the Gold Standard Gene Database (if you believe it has been experimentally validated) (info).
Post a comment about this gene to appear on this page (info).

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Function Predictions
Source Predicted function(s)
NCBI Protein Cluster Prediction peptidyl-tRNA hydrolase
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group 3.1.1.29: Aminoacyl-tRNA hydrolase. / (References: 19435885)

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Supporting Functional Information
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
EC number
BLASTP hits to experimentally validated proteins
green pth from Staphylococcus aureus
(%_identity=34.59; E_val=7e-28; BitScore=118.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green pth from Chlamydia muridarum Nigg

to see the rest 2 gene click here
GO terms
  • MF: GO:0004045 : aminoacyl-tRNA hydrolase activity : IEA
  • CC: GO:0005737 : cytoplasm : IEA
  • BP: GO:0006412 : translation : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • PTH: Peptidyl-tRNA hydrolase (PTH) is a monomeric protein that cleaves the ester bond linking the nascent peptide and tRNA wh.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database

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Functionally Linked Genes
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see www.java.com
 OperonDB
gene neighbourhoods
phylogenetic profile
HP1499hypothetical protein
 
  
HP1498hypothetical protein
 
  
HP1495transaldolase
 
  
HP149650S ribosomal protein L25/general stress protein C
 
 
 
frrribosome recycling factor  
 
HP0355GTP-binding protein LepA  
 
HP1245single-stranded DNA-binding protein  
 
HP0956hypothetical protein  
 
obgEGTPase ObgE  
 
prfApeptide chain release factor 1  
 
HP0559acyl carrier protein (acpP)  
 
rpmI50S ribosomal protein L35  
 
rplI50S ribosomal protein L9  
 
tufelongation factor Tu  
 
HP0013hypothetical protein  
 
mnmAtRNA-specific 2-thiouridylase MnmA  
 
rpsP30S ribosomal protein S16  
 
HP0286cell division protein (ftsH)  
 
fmtmethionyl-tRNA formyltransferase  
 
rpsF30S ribosomal protein S6  
 
aspSaspartyl-tRNA synthetase  
 
rplQ50S ribosomal protein L17  
 
HP0745hypothetical protein  
 
tsfelongation factor Ts  
 
HP0962acyl carrier protein (acpP)  
 
rncribonuclease III  
 
rplS50S ribosomal protein L19  
 
HP1069cell division protein (ftsH)  
 
rpsR30S ribosomal protein S18  
 
rplL50S ribosomal protein L7/L12  
 
HP0347hypothetical protein  
 
rpmA50S ribosomal protein L27  
 
HP1450putative inner membrane protein translocase compon  
 
rpmG50S ribosomal protein L33  
 

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Phenotype data
Phenotype Description Expression
Class		 Reference(s)
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)