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Gene HP1478 from Helicobacter pylori 26695: DNA helicase II (uvrD)
Member of NCBI Protein Clusters CLSK872561(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899814
UniProtKB accession
RefSeq Protein accession NP_208269.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: HP1478
  • locus tag: HP1478
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Post a comment about this gene to appear on this page (info).
Source Predicted function(s)
NCBI Protein Cluster Prediction ATP-dependent DNA helicase UvrD
Prof. David Horn 3.6.1: acting on Phosphorous containing anhydrides / (References: 20034383)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043140 ATP-dependent 3'-5' DNA helicase activity / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green BAS0291 from Bacillus anthracis str. Sterne
(%_identity=35.9; E_val=6e-103; BitScore=370.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green rexA from Lactococcus lactis subsp. cremoris MG1363

to see the rest 12 genes click here
GO terms
  • MF: GO:0000166 : nucleotide binding : IEA
  • MF: GO:0005524 : ATP binding : IEA
  • BP: GO:0006281 : DNA repair : IEA
  • MF: GO:0004003 : ATP-dependent DNA helicase activity : IEA
  • MF: GO:0003677 : DNA binding : IEA
  • MF: GO:0004386 : helicase activity : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
Domain Structure from CDD
  • UvrD: Superfamily I DNA and RNA helicases [DNA replication, recombination, and repair]
  • UvrD-helicase: UvrD/REP helicase. exonuclease V subunit beta; Provisional
  • DUF699: Putative ATPase (DUF699). exonuclease V subunit alpha; Provisional

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP1480seryl-tRNA synthetase
HP1479hypothetical protein
HP14763-octaprenyl-4-hydroxybenzoate carboxy-lyase
flgAflagellar basal body P-ring biosynthesis protein F
HP0110co-chaperone and heat shock protein (grpE) 
Phenotype Description Expression
Candidate essential gene Identified as essential gene in one or more studies (see references) Knock out
PMID: 15547264
(candidate essential)