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Gene trmE from Helicobacter pylori 26695: tRNA modification GTPase TrmE
Member of NCBI Protein Clusters PRK05291(See COMBREX Page ) (See NCBI page)
NCBI Entrez GeneID 899841
UniProtKB accession
RefSeq Protein accession NP_208243.1 (PROVISIONAL)
Gene Symbol(s)
  • symbol: trmE
  • locus tag: HP1452
  • aliases: mnmE, thdF
Organism Helicobacter pylori 26695 (NCBI TaxID: 85962)
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Contribute a predicted function for this gene (free text, GO terms, or EC number) (info). Be sure to check the list of current predicted functions in the section immediately below beforehand.
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Source Predicted function(s)
NCBI Protein Cluster Prediction tRNA modification GTPase TrmE
Berkeley Phylogenomics Group GO:0042803 protein homodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0051219 phosphoprotein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0003924 GTPase activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0042802 identical protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019843 rRNA binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0043022 ribosome binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005545 phosphatidylinositol binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0046982 protein heterodimerization activity / (References: 19435885)
Berkeley Phylogenomics Group GO:0005525 GTP binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0005515 protein binding / (References: 19435885)
Berkeley Phylogenomics Group GO:0019003 GDP binding / (References: 19435885)
Functional Status blueblue (function predicted, no experimental evidence)
Source of prediction NCBI Protein Clusters info
BLASTP hits to experimentally validated proteins
green trmE from Thermotoga maritima MSB8
(%_identity=38.77; E_val=7e-76; BitScore=279.0)

other hits with E-value < 1e-05
Share the same Pfam domain composition with the following experimentally validated proteins
green mnmE from Escherichia coli str. K-12 substr. MG1655

to see the rest 2 gene click here
GO terms
  • MF: GO:0046872 : metal ion binding : IEA
  • CC: GO:0005622 : intracellular : IEA
  • BP: GO:0008033 : tRNA processing : IEA
  • BP: GO:0006400 : tRNA modification : IEA
  • MF: GO:0005525 : GTP binding : IEA
  • MF: GO:0016787 : hydrolase activity : IEA
  • MF: GO:0003924 : GTPase activity : IEA
  • MF: GO:0000166 : nucleotide binding : IEA
  • CC: GO:0005737 : cytoplasm : IEA
Domain Structure from CDD
  • mnmE_trmE_thdF: tRNA modification GTPase TrmE. TrmE, also called MnmE and previously designated ThdF (thiophene and furan oxidation prot.... (More)
  • TrmE_N: GTP-binding protein TrmE N-terminus. This family represents the shorter, B, chain of the homo-dimeric structure which is.... (More)
  • trmE: TrmE (MnmE, ThdF, MSS1) is a 3-domain protein found in bacteria and eukaryotes. It controls modification of the uridine.... (More)

See domain structure on NCBI Conserved Domain Database
Domain structure from Pfam
See domain structure on Pfam Database
The table at right lists genes that may be "functionally linked to" (i.e., participate in a common biological process, or form a protein complex with) the subject gene of this page, as determined by two sequence-independent methods, including phylogenetic profiling and operon membership (determined by OperonDB). (Info.) These linkages may also be viewed graphically using the program VisANT, by clicking on the headers of the table. Note: VisANT requires Java. To install the latest version of Java, see
phylogenetic profile
HP1453hypothetical protein
HP1450putative inner membrane protein translocase compon
HP1451hypothetical protein
rpmF50S ribosomal protein L32 
gidAtRNA uridine 5-carboxymethylaminomethyl modificati